Assay Detail
Binding
CHEMBL4417843
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity to human Dab2 DH domain (33 to 191 residues) expressed in Escherichia coli BL21 (DE3) RIL cells pre-incubated for 10 to 15 mins before fluorescently labeled peptide addition by fluorescence polarization assay
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Disabled homolog 2-interacting protein (CHEMBL4523330) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Dab2 inhibitors for the prevention and treatment of cystic fibrosis
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 8 | 6.30 | 6.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4579552 | — | — | 1 | 6.82 |
| CHEMBL4469853 | — | — | 1 | 6.81 |
| CHEMBL4469619 | — | — | 1 | 6.41 |
| CHEMBL1344136 | — | — | 1 | 6.11 |
| CHEMBL467987 | — | — | 1 | 5.90 |
| CHEMBL1380684 | — | — | 1 | 5.72 |
| CHEMBL1530550 | — | — | 1 | - |
| CHEMBL1600223 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4579552 | — | Ki | = | 150.0 | nM | 6.82 |
| CHEMBL4469853 | — | Ki | = | 155.0 | nM | 6.81 |
| CHEMBL4469619 | — | Ki | = | 390.0 | nM | 6.41 |
| CHEMBL1344136 | — | Ki | = | 779.0 | nM | 6.11 |
| CHEMBL467987 | — | Ki | = | 1260.0 | nM | 5.90 |
| CHEMBL1380684 | — | Ki | = | 1920.0 | nM | 5.72 |
| CHEMBL1530550 | — | Ki | - | — | - | |
| CHEMBL1600223 | — | Ki | - | — | - |