Assay Detail
Binding
CHEMBL4418029
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human recombinant ACMSD1 expressed in Escherichia coli BL21 (DE3) cells assessed as reduction in conversion of 3-OH-anthranilic acid into ACMS by spectrophotometry
22
Total Activities
22
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
2-amino-3-carboxymuconate-6-semialdehyde decarboxylase (CHEMBL4105941) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Inhibitors of alpha-amino-beta-carboxymuconic acid semialdehyde decarboxylase
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 22 | 6.88 | 8.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4072240 | — | — | 1 | 8.30 |
| CHEMBL4071212 | — | — | 1 | 8.00 |
| CHEMBL4100715 | — | — | 1 | 7.92 |
| CHEMBL4553502 | — | — | 1 | 7.60 |
| CHEMBL4578242 | — | — | 1 | 7.51 |
| CHEMBL4437596 | — | — | 1 | 7.31 |
| CHEMBL4067706 | — | — | 1 | 7.30 |
| CHEMBL4580504 | — | — | 1 | 7.18 |
| CHEMBL4097581 | — | — | 1 | 7.15 |
| CHEMBL4066693 | — | — | 1 | 7.11 |
| CHEMBL4470922 | — | — | 1 | 7.09 |
| CHEMBL4465329 | — | — | 1 | 7.09 |
| CHEMBL4458077 | — | — | 1 | 7.06 |
| CHEMBL4449573 | — | — | 1 | 6.96 |
| CHEMBL4070405 | — | — | 1 | 6.87 |
| CHEMBL4061780 | — | — | 1 | 6.13 |
| CHEMBL4448895 | — | — | 1 | 6.12 |
| CHEMBL4530111 | — | — | 1 | 6.02 |
| CHEMBL4088930 | — | — | 1 | 5.96 |
| CHEMBL4067044 | — | — | 1 | 5.77 |
| CHEMBL4459014 | — | — | 1 | 5.70 |
| CHEMBL4468205 | — | — | 1 | 5.31 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4072240 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL4071212 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL4100715 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL4553502 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL4578242 | — | IC50 | = | 31.0 | nM | 7.51 |
| CHEMBL4437596 | — | IC50 | = | 49.0 | nM | 7.31 |
| CHEMBL4067706 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL4580504 | — | IC50 | = | 66.0 | nM | 7.18 |
| CHEMBL4097581 | — | IC50 | = | 71.0 | nM | 7.15 |
| CHEMBL4066693 | — | IC50 | = | 77.0 | nM | 7.11 |
| CHEMBL4470922 | — | IC50 | = | 82.0 | nM | 7.09 |
| CHEMBL4465329 | — | IC50 | = | 82.0 | nM | 7.09 |
| CHEMBL4458077 | — | IC50 | = | 88.0 | nM | 7.06 |
| CHEMBL4449573 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL4070405 | — | IC50 | = | 136.0 | nM | 6.87 |
| CHEMBL4061780 | — | IC50 | = | 740.0 | nM | 6.13 |
| CHEMBL4448895 | — | IC50 | = | 760.0 | nM | 6.12 |
| CHEMBL4530111 | — | IC50 | = | 960.0 | nM | 6.02 |
| CHEMBL4088930 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL4067044 | — | IC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL4459014 | — | IC50 | = | 1990.0 | nM | 5.70 |
| CHEMBL4468205 | — | IC50 | = | 4900.0 | nM | 5.31 |