Assay Detail
Binding
CHEMBL4418244
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Inhibition of FTO (unknown origin) assessed as reduction in demethylation using 39nt-m6 A-ssDNA and 2OG incubated for 2 hrs by non-denaturing polyacrylamide electrophoresis method
27
Total Activities
27
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Alpha-ketoglutarate-dependent dioxygenase FTO (CHEMBL2331065) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Use of 2-(substituted phenylamino)benzoic acid fto inhibitor in treating leukemia
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 27 | 5.01 | 7.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4572939 | — | — | 1 | 7.22 |
| CHEMBL4532629 | — | — | 1 | 6.40 |
| CHEMBL4563024 | — | — | 1 | 6.16 |
| CHEMBL4442310 | — | — | 1 | 5.96 |
| CHEMBL4563561 | — | — | 1 | 5.94 |
| CHEMBL4471728 | — | — | 1 | 5.92 |
| CHEMBL4567838 | — | — | 1 | 5.80 |
| CHEMBL4521076 | — | — | 1 | 5.34 |
| CHEMBL4559749 | — | — | 1 | 5.12 |
| CHEMBL4460597 | — | — | 1 | 4.52 |
| CHEMBL4474254 | — | — | 1 | 4.52 |
| CHEMBL4453402 | — | — | 1 | 4.52 |
| CHEMBL4517902 | — | — | 1 | 4.52 |
| CHEMBL4435677 | — | — | 1 | 4.52 |
| CHEMBL4576909 | — | — | 1 | 4.52 |
| CHEMBL4563246 | — | — | 1 | 4.52 |
| CHEMBL4576737 | — | — | 1 | 4.52 |
| CHEMBL4471543 | — | — | 1 | 4.52 |
| CHEMBL4470475 | — | — | 1 | 4.52 |
| CHEMBL4561283 | — | — | 1 | 4.52 |
| CHEMBL4522884 | — | — | 1 | 4.52 |
| CHEMBL4446803 | — | — | 1 | 4.52 |
| CHEMBL4436454 | — | — | 1 | 4.52 |
| CHEMBL4436398 | — | — | 1 | 4.52 |
| CHEMBL4452472 | — | — | 1 | 4.52 |
| CHEMBL4560665 | — | — | 1 | 4.52 |
| CHEMBL4463988 | — | — | 1 | 4.52 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4572939 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL4532629 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL4563024 | — | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL4442310 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL4563561 | — | IC50 | = | 1140.0 | nM | 5.94 |
| CHEMBL4471728 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL4567838 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL4521076 | — | IC50 | = | 4600.0 | nM | 5.34 |
| CHEMBL4559749 | — | IC50 | = | 7600.0 | nM | 5.12 |
| CHEMBL4460597 | — | IC50 | = | 30000.0 | nM | 4.52 |
| CHEMBL4474254 | — | IC50 | = | 30000.0 | nM | 4.52 |
| CHEMBL4453402 | — | IC50 | = | 30000.0 | nM | 4.52 |
| CHEMBL4517902 | — | IC50 | = | 30000.0 | nM | 4.52 |
| CHEMBL4435677 | — | IC50 | = | 30000.0 | nM | 4.52 |
| CHEMBL4576909 | — | IC50 | = | 30000.0 | nM | 4.52 |
| CHEMBL4563246 | — | IC50 | = | 30000.0 | nM | 4.52 |
| CHEMBL4576737 | — | IC50 | = | 30000.0 | nM | 4.52 |
| CHEMBL4471543 | — | IC50 | = | 30000.0 | nM | 4.52 |
| CHEMBL4470475 | — | IC50 | = | 30000.0 | nM | 4.52 |
| CHEMBL4561283 | — | IC50 | = | 30000.0 | nM | 4.52 |
| CHEMBL4522884 | — | IC50 | = | 30000.0 | nM | 4.52 |
| CHEMBL4446803 | — | IC50 | = | 30000.0 | nM | 4.52 |
| CHEMBL4436454 | — | IC50 | = | 30000.0 | nM | 4.52 |
| CHEMBL4436398 | — | IC50 | = | 30000.0 | nM | 4.52 |
| CHEMBL4452472 | — | IC50 | = | 30000.0 | nM | 4.52 |
| CHEMBL4560665 | — | IC50 | = | 30000.0 | nM | 4.52 |
| CHEMBL4463988 | — | IC50 | = | 30000.0 | nM | 4.52 |