Assay Detail
Binding
CHEMBL4418337
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antagonist activity at CX3CR1 (unknown origin) expressed in mouse B300 cells assessed as inhibition of fractalkine-induced chemotaxis incubated for 30 mins and measured after 3.5 hrs by Cell Titer assay
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Pyrrolidine-3-ylacetic acid derivative
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 7.96 | 8.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4518556 | — | — | 1 | 8.40 |
| CHEMBL4539605 | — | — | 1 | 8.30 |
| CHEMBL4577003 | — | — | 1 | 8.22 |
| CHEMBL4474066 | — | — | 1 | 8.22 |
| CHEMBL4475030 | — | — | 1 | 7.96 |
| CHEMBL4442967 | — | — | 1 | 7.92 |
| CHEMBL4565523 | — | — | 1 | 7.89 |
| CHEMBL4551880 | — | — | 1 | 7.85 |
| CHEMBL4435586 | — | — | 1 | 7.80 |
| CHEMBL4443425 | — | — | 1 | 7.80 |
| CHEMBL4456446 | — | — | 1 | 7.68 |
| CHEMBL4447653 | — | — | 1 | 7.51 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4518556 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL4539605 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL4577003 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL4474066 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL4475030 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL4442967 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL4565523 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL4551880 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL4435586 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL4443425 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL4456446 | — | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL4447653 | — | IC50 | = | 31.0 | nM | 7.51 |