Assay Detail
Binding
CHEMBL4418424
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Binding affinity to full length recombinant truncated non-catalytic N-terminal transmembrane helix containing C-terminal 4xHis tagged human CYP2A13dH expressed in Escherichia coli by HTS assay
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Morpholines as selective inhibitors of cytochrome P450 2A13
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 11 | 4.82 | 5.72 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4437617 | — | — | 1 | 5.72 |
| CHEMBL4575324 | — | — | 1 | 5.24 |
| CHEMBL4452645 | — | — | 1 | 5.16 |
| CHEMBL2262739 | — | — | 1 | 5.14 |
| CHEMBL1479903 | — | — | 1 | 5.00 |
| CHEMBL4471036 | — | — | 1 | 4.71 |
| CHEMBL4526174 | — | — | 1 | 4.54 |
| CHEMBL4440592 | — | — | 1 | 4.54 |
| CHEMBL4543246 | — | — | 1 | 4.46 |
| CHEMBL4463540 | — | — | 1 | 4.42 |
| CHEMBL4465634 | — | — | 1 | 4.14 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4437617 | — | Kd | = | 1900.0 | nM | 5.72 |
| CHEMBL4575324 | — | Kd | = | 5800.0 | nM | 5.24 |
| CHEMBL4452645 | — | Kd | = | 7000.0 | nM | 5.16 |
| CHEMBL2262739 | — | Kd | = | 7300.0 | nM | 5.14 |
| CHEMBL1479903 | — | Kd | = | 10000.0 | nM | 5.00 |
| CHEMBL4471036 | — | Kd | = | 19300.0 | nM | 4.71 |
| CHEMBL4526174 | — | Kd | = | 28500.0 | nM | 4.54 |
| CHEMBL4440592 | — | Kd | = | 28750.0 | nM | 4.54 |
| CHEMBL4543246 | — | Kd | = | 35000.0 | nM | 4.46 |
| CHEMBL4463540 | — | Kd | = | 37700.0 | nM | 4.42 |
| CHEMBL4465634 | — | Kd | = | 72500.0 | nM | 4.14 |