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Compound Detail

CHEMBL4437617

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Clc1cccc(Cl)c1CN1CCOCC1

Basic Information

ChEMBL ID CHEMBL4437617
Phase Preclinical
Structure Type MOL
InChI Key MUOVEEIXKXOODD-UHFFFAOYSA-N
1
Targets
2
Activities
1
Assay Types
0
PK Parameters
0
Publications
0
Known Names

Molecular Properties

246.1
MW (Da)
2.83
ALogP
2
HBA
0
HBD
12.5
PSA (Ų)
0.80
QED
0
Ro5 Violations
2
Rot. Bonds

Drug Information

Molecule Type Unknown
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C11H13Cl2NO
MW 246.14
Aromatic Rings 1
Heavy Atoms 15
NP-Likeness -1.75

Activity Summary

Kd 2 meas. best 5.72

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Cytochrome P450 2A13
CHEMBL3542436
Kd 5.72 5.72 1900.0 1

Activity Data Samples

Top measurements by pChEMBL value

Target Type Rel. Value Units pChEMBL Assay PubMed
Cytochrome P450 2A13 Kd = 1900.0 nM 5.72 Binding affinity to full length recombinant truncated non-catalytic N-terminal t... -

Data from ChEMBL 36 via Core Engine