Assay Detail
Binding
CHEMBL4418739
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Inhibition of FTO (unknown origin) assessed as reduction in demethylation by measuring N6-mA and A level incubated for 2 hrs by HPLC-MS/MS analysis
119
Total Activities
119
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Alpha-ketoglutarate-dependent dioxygenase FTO (CHEMBL2331065) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
FTO inhibitors
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 119 | 5.97 | 6.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4453979 | — | — | 1 | 6.00 |
| CHEMBL4438114 | — | — | 1 | 6.00 |
| CHEMBL4440198 | — | — | 1 | 6.00 |
| CHEMBL4441097 | — | — | 1 | 6.00 |
| CHEMBL4476272 | — | — | 1 | 6.00 |
| CHEMBL4531642 | — | — | 1 | 6.00 |
| CHEMBL4476652 | — | — | 1 | 6.00 |
| CHEMBL525388 | — | — | 1 | 6.00 |
| CHEMBL469803 | — | — | 1 | 6.00 |
| CHEMBL4474943 | — | — | 1 | 6.00 |
| CHEMBL4557292 | — | — | 1 | 6.00 |
| CHEMBL4572182 | — | — | 1 | 6.00 |
| CHEMBL4564612 | — | — | 1 | 6.00 |
| CHEMBL4558186 | — | — | 1 | 6.00 |
| CHEMBL4522359 | — | — | 1 | 6.00 |
| CHEMBL4592513 | — | — | 1 | 6.00 |
| CHEMBL4474241 | — | — | 1 | 6.00 |
| CHEMBL4570495 | — | — | 1 | 6.00 |
| CHEMBL953 | ENTACAPONE | 4.0 | 1 | 5.52 |
| CHEMBL4457912 | — | — | 1 | - |
| CHEMBL4462025 | — | — | 1 | - |
| CHEMBL4461517 | — | — | 1 | - |
| CHEMBL4461985 | — | — | 1 | - |
| CHEMBL4435468 | — | — | 1 | - |
| CHEMBL4551735 | — | — | 1 | - |
| CHEMBL4467308 | — | — | 1 | - |
| CHEMBL4529597 | — | — | 1 | - |
| CHEMBL4468321 | — | — | 1 | - |
| CHEMBL4569935 | — | — | 1 | - |
| CHEMBL4461072 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4438114 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL4570495 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL4474241 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL4592513 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL4453979 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL4522359 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL4558186 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL4564612 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL4572182 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL4557292 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL469803 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL525388 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL4476652 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL4531642 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL4476272 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL4441097 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL4440198 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL4474943 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL953 | ENTACAPONE | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL4440482 | — | IC50 | < | 10000.0 | nM | - |
| CHEMBL4438619 | — | IC50 | < | 10000.0 | nM | - |
| CHEMBL4436213 | — | IC50 | < | 10000.0 | nM | - |
| CHEMBL4589043 | — | IC50 | < | 10000.0 | nM | - |
| CHEMBL4566060 | — | IC50 | < | 10000.0 | nM | - |
| CHEMBL4448540 | — | IC50 | < | 10000.0 | nM | - |
| CHEMBL4552937 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL4547019 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL4468321 | — | IC50 | < | 10000.0 | nM | - |
| CHEMBL4585926 | — | IC50 | < | 10000.0 | nM | - |
| CHEMBL4440149 | — | IC50 | < | 10000.0 | nM | - |
| CHEMBL4563060 | — | IC50 | <= | 300.0 | nM | - |
| CHEMBL4565157 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL4448030 | — | IC50 | <= | 250.0 | nM | - |
| CHEMBL4527360 | — | IC50 | <= | 500.0 | nM | - |
| CHEMBL4437992 | — | IC50 | < | 10000.0 | nM | - |
| CHEMBL4451781 | — | IC50 | < | 10000.0 | nM | - |
| CHEMBL4553802 | — | IC50 | < | 10000.0 | nM | - |
| CHEMBL4546267 | — | IC50 | < | 10000.0 | nM | - |
| CHEMBL4573399 | — | IC50 | < | 10000.0 | nM | - |
| CHEMBL4468262 | — | IC50 | < | 10000.0 | nM | - |
| CHEMBL4518568 | — | IC50 | < | 10000.0 | nM | - |
| CHEMBL4537989 | — | IC50 | < | 10000.0 | nM | - |
| CHEMBL499081 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL4435048 | — | IC50 | < | 1000.0 | nM | - |
| CHEMBL4586671 | — | IC50 | < | 10000.0 | nM | - |
| CHEMBL4551735 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL4566854 | — | IC50 | < | 10000.0 | nM | - |
| CHEMBL4447412 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL4565882 | — | IC50 | < | 10000.0 | nM | - |
| CHEMBL4563403 | — | IC50 | < | 10000.0 | nM | - |