Assay Detail
Binding
CHEMBL4418864
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of N-terminal MBP tagged human neuraminidase-2 expressed in Escherichia coli pre-incubated for 15 mins before 4MU-NANA substrate addition and measured after 30 mins by fluorescence based assay
67
Total Activities
67
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Methods of preventing or treating atherosclerosis with inhibitors of specific isoenzymes of human neuraminidase
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 67 | 4.59 | 5.68 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4277689 | — | — | 1 | 5.68 |
| CHEMBL4280792 | — | — | 1 | 5.48 |
| CHEMBL4278858 | — | — | 1 | 5.36 |
| CHEMBL4277391 | — | — | 1 | 5.34 |
| CHEMBL4099818 | — | — | 1 | 5.23 |
| CHEMBL4284515 | — | — | 1 | 5.16 |
| CHEMBL222813 | ZANAMIVIR | 4.0 | 1 | 5.11 |
| CHEMBL4291435 | — | — | 1 | 4.89 |
| CHEMBL4291908 | — | — | 1 | 4.82 |
| CHEMBL4291991 | — | — | 1 | 4.70 |
| CHEMBL4467946 | — | — | 1 | 4.68 |
| CHEMBL4291325 | — | — | 1 | 4.58 |
| CHEMBL4286830 | — | — | 1 | 4.51 |
| CHEMBL4293651 | — | — | 1 | 4.50 |
| CHEMBL4076203 | — | — | 1 | 4.50 |
| CHEMBL4440333 | — | — | 1 | 4.48 |
| CHEMBL96712 | NEU5AC2EN | — | 1 | 4.43 |
| CHEMBL4289583 | — | — | 1 | 4.43 |
| CHEMBL4295174 | — | — | 1 | 4.41 |
| CHEMBL4288490 | — | — | 1 | 4.40 |
| CHEMBL4290966 | — | — | 1 | 4.39 |
| CHEMBL4064112 | — | — | 1 | 4.35 |
| CHEMBL4290253 | — | — | 1 | 4.33 |
| CHEMBL4288030 | — | — | 1 | 4.30 |
| CHEMBL4283482 | — | — | 1 | 4.23 |
| CHEMBL4281100 | — | — | 1 | 4.22 |
| CHEMBL4292800 | — | — | 1 | 4.12 |
| CHEMBL4076383 | — | — | 1 | 4.11 |
| CHEMBL4062382 | — | — | 1 | 4.08 |
| CHEMBL4277834 | — | — | 1 | 4.07 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4277689 | — | IC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL4280792 | — | IC50 | = | 3300.0 | nM | 5.48 |
| CHEMBL4278858 | — | IC50 | = | 4400.0 | nM | 5.36 |
| CHEMBL4277391 | — | IC50 | = | 4600.0 | nM | 5.34 |
| CHEMBL4099818 | — | IC50 | = | 5900.0 | nM | 5.23 |
| CHEMBL4284515 | — | IC50 | = | 7000.0 | nM | 5.16 |
| CHEMBL222813 | ZANAMIVIR | IC50 | = | 7800.0 | nM | 5.11 |
| CHEMBL4291435 | — | IC50 | = | 13000.0 | nM | 4.89 |
| CHEMBL4291908 | — | IC50 | = | 15000.0 | nM | 4.82 |
| CHEMBL4291991 | — | IC50 | = | 20000.0 | nM | 4.70 |
| CHEMBL4467946 | — | IC50 | = | 21000.0 | nM | 4.68 |
| CHEMBL4291325 | — | IC50 | = | 26000.0 | nM | 4.58 |
| CHEMBL4286830 | — | IC50 | = | 31000.0 | nM | 4.51 |
| CHEMBL4076203 | — | IC50 | = | 32000.0 | nM | 4.50 |
| CHEMBL4293651 | — | IC50 | = | 32000.0 | nM | 4.50 |
| CHEMBL4440333 | — | IC50 | = | 33000.0 | nM | 4.48 |
| CHEMBL96712 | NEU5AC2EN | IC50 | = | 37000.0 | nM | 4.43 |
| CHEMBL4289583 | — | IC50 | = | 37000.0 | nM | 4.43 |
| CHEMBL4295174 | — | IC50 | = | 39000.0 | nM | 4.41 |
| CHEMBL4288490 | — | IC50 | = | 40000.0 | nM | 4.40 |
| CHEMBL4290966 | — | IC50 | = | 41000.0 | nM | 4.39 |
| CHEMBL4064112 | — | IC50 | = | 45000.0 | nM | 4.35 |
| CHEMBL4290253 | — | IC50 | = | 47000.0 | nM | 4.33 |
| CHEMBL4288030 | — | IC50 | = | 50000.0 | nM | 4.30 |
| CHEMBL4283482 | — | IC50 | = | 59000.0 | nM | 4.23 |
| CHEMBL4281100 | — | IC50 | = | 60000.0 | nM | 4.22 |
| CHEMBL4292800 | — | IC50 | = | 76000.0 | nM | 4.12 |
| CHEMBL4076383 | — | IC50 | = | 78000.0 | nM | 4.11 |
| CHEMBL4062382 | — | IC50 | = | 84000.0 | nM | 4.08 |
| CHEMBL4277834 | — | IC50 | = | 86000.0 | nM | 4.07 |
| CHEMBL4279510 | — | IC50 | = | 90000.0 | nM | 4.05 |
| CHEMBL4283057 | — | IC50 | = | 90000.0 | nM | 4.05 |
| CHEMBL4073992 | — | IC50 | > | 500000.0 | nM | - |
| CHEMBL4081811 | — | IC50 | > | 500000.0 | nM | - |
| CHEMBL4060974 | — | IC50 | = | 430000.0 | nM | - |
| CHEMBL4071732 | — | IC50 | = | 110000.0 | nM | - |
| CHEMBL4069646 | — | IC50 | = | 360000.0 | nM | - |
| CHEMBL4454422 | — | IC50 | = | 110000.0 | nM | - |
| CHEMBL4294428 | — | IC50 | > | 500000.0 | nM | - |
| CHEMBL4076483 | — | IC50 | > | 500000.0 | nM | - |
| CHEMBL4289116 | — | IC50 | > | 500000.0 | nM | - |
| CHEMBL4279593 | — | IC50 | = | 170000.0 | nM | - |
| CHEMBL4291251 | — | IC50 | = | 220000.0 | nM | - |
| CHEMBL4286541 | — | IC50 | = | 410000.0 | nM | - |
| CHEMBL4294661 | — | IC50 | = | 160000.0 | nM | - |
| CHEMBL4080360 | — | IC50 | = | 250000.0 | nM | - |
| CHEMBL1289198 | — | IC50 | > | 500000.0 | nM | - |
| CHEMBL4294730 | — | IC50 | = | 140000.0 | nM | - |
| CHEMBL4089157 | — | IC50 | = | 290000.0 | nM | - |
| CHEMBL4280607 | — | IC50 | = | 120000.0 | nM | - |