Assay Detail
Binding
CHEMBL4418883
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Inhibition of N-terminal MBP tagged human neuraminidase-3 expressed in Escherichia coli pre-incubated for 15 mins before GM3 substrate addition and measured after 30 mins by fluorescence based assay
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Methods of preventing or treating atherosclerosis with inhibitors of specific isoenzymes of human neuraminidase
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 4.87 | 5.42 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4099818 | — | — | 1 | 5.42 |
| CHEMBL4076203 | — | — | 1 | 4.92 |
| CHEMBL96712 | NEU5AC2EN | — | 1 | 4.27 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4099818 | — | IC50 | = | 3800.0 | nM | 5.42 |
| CHEMBL4076203 | — | IC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL96712 | NEU5AC2EN | IC50 | = | 54000.0 | nM | 4.27 |