Assay Detail
Functional
CHEMBL4419131
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Activity at human TAS2R10 expressed in HEK-293T-Galpha16-gustducin44 cells assessed as effect on calcium response by FLIPR assay
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Bitter taste receptors
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 3 | 4.26 | 4.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL227934 | STRYCHNINE | -1.0 | 1 | 4.40 |
| CHEMBL501756 | BRUCINE | -1.0 | 1 | 4.22 |
| CHEMBL6067658 | DENATONIUM BENZOATE | 2.0 | 1 | 4.16 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL227934 | STRYCHNINE | EC50 | = | 40000.0 | nM | 4.40 |
| CHEMBL501756 | BRUCINE | EC50 | = | 60000.0 | nM | 4.22 |
| CHEMBL6067658 | DENATONIUM BENZOATE | EC50 | = | 70000.0 | nM | 4.16 |