Skip to main content
Free research Free research Free assay review with research home and workspace preview
Quick search ChEMBL 36
Assay Detail

CHEMBL4419593

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of C-terminus 10x-His-taged human TFPI-1 (29 to 282 residues) assessed as inhibition of factor 10a using S-2222 substrate incubated for 115 mins by micro-plate reader based assay
ChEMBL ↗
253
Total Activities
253
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Tissue factor pathway inhibitor (CHEMBL3713062) ↗
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

TFPI inhibitors and methods of use
(2013)

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
EC50 253 6.18 8.92

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL4445250 — — 1 8.92
CHEMBL4447812 — — 1 8.68
CHEMBL4454272 — — 1 8.68
CHEMBL4530936 — — 1 8.62
CHEMBL4449468 — — 1 8.32
CHEMBL3894172 — — 1 7.70
CHEMBL3899635 — — 1 7.52
CHEMBL4545754 — — 1 7.40
CHEMBL4568357 — — 1 7.30
CHEMBL3975755 — — 1 7.30
CHEMBL3950682 — — 1 7.30
CHEMBL3974158 — — 1 7.22
CHEMBL3958046 — — 1 7.22
CHEMBL4442500 — — 1 7.10
CHEMBL3984087 — — 1 7.05
CHEMBL3980096 — — 1 7.00
CHEMBL4472071 — — 1 7.00
CHEMBL3978085 — — 1 6.92
CHEMBL3969514 — — 1 6.89
CHEMBL3908913 — — 1 6.89
CHEMBL3935596 — — 1 6.89
CHEMBL3953204 — — 1 6.82
CHEMBL3976722 — — 1 6.80
CHEMBL3904040 — — 1 6.80
CHEMBL3926366 — — 1 6.77
CHEMBL3965457 — — 1 6.77
CHEMBL3910796 — — 1 6.75
CHEMBL3920502 — — 1 6.75
CHEMBL3916916 — — 1 6.75
CHEMBL4449783 — — 1 6.72

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL4445250 — EC50 = 1.2 nM 8.92
CHEMBL4454272 — EC50 = 2.1 nM 8.68
CHEMBL4447812 — EC50 = 2.1 nM 8.68
CHEMBL4530936 — EC50 = 2.4 nM 8.62
CHEMBL4449468 — EC50 = 4.8 nM 8.32
CHEMBL3894172 — EC50 = 20.0 nM 7.70
CHEMBL3899635 — EC50 = 30.0 nM 7.52
CHEMBL4545754 — EC50 = 40.0 nM 7.40
CHEMBL3950682 — EC50 = 50.0 nM 7.30
CHEMBL4568357 — EC50 = 50.3 nM 7.30
CHEMBL3975755 — EC50 = 50.0 nM 7.30
CHEMBL3958046 — EC50 = 60.0 nM 7.22
CHEMBL3974158 — EC50 = 60.0 nM 7.22
CHEMBL4442500 — EC50 = 80.0 nM 7.10
CHEMBL3984087 — EC50 = 90.0 nM 7.05
CHEMBL4472071 — EC50 = 100.0 nM 7.00
CHEMBL3980096 — EC50 = 100.0 nM 7.00
CHEMBL3978085 — EC50 = 120.0 nM 6.92
CHEMBL3935596 — EC50 = 130.0 nM 6.89
CHEMBL3908913 — EC50 = 130.0 nM 6.89
CHEMBL3969514 — EC50 = 130.0 nM 6.89
CHEMBL3953204 — EC50 = 152.3 nM 6.82
CHEMBL3904040 — EC50 = 160.0 nM 6.80
CHEMBL3976722 — EC50 = 160.0 nM 6.80
CHEMBL3926366 — EC50 = 170.0 nM 6.77
CHEMBL3965457 — EC50 = 170.0 nM 6.77
CHEMBL3916916 — EC50 = 180.0 nM 6.75
CHEMBL3920502 — EC50 = 180.0 nM 6.75
CHEMBL3910796 — EC50 = 180.0 nM 6.75
CHEMBL3976800 — EC50 = 190.0 nM 6.72
CHEMBL3961042 — EC50 = 190.0 nM 6.72
CHEMBL4449783 — EC50 = 190.0 nM 6.72
CHEMBL3892215 — EC50 = 200.0 nM 6.70
CHEMBL4453765 — EC50 = 200.0 nM 6.70
CHEMBL3949179 — EC50 = 200.0 nM 6.70
CHEMBL3927717 — EC50 = 210.0 nM 6.68
CHEMBL4530715 — EC50 = 210.0 nM 6.68
CHEMBL3961378 — EC50 = 210.0 nM 6.68
CHEMBL3897272 — EC50 = 220.0 nM 6.66
CHEMBL3958468 — EC50 = 220.0 nM 6.66
CHEMBL3958681 — EC50 = 220.0 nM 6.66
CHEMBL3949739 — EC50 = 220.0 nM 6.66
CHEMBL3891294 — EC50 = 230.0 nM 6.64
CHEMBL4446952 — EC50 = 240.0 nM 6.62
CHEMBL3906782 — EC50 = 240.0 nM 6.62
CHEMBL3952366 — EC50 = 240.0 nM 6.62
CHEMBL3960826 — EC50 = 250.0 nM 6.60
CHEMBL3907128 — EC50 = 250.0 nM 6.60
CHEMBL3937934 — EC50 = 250.0 nM 6.60
CHEMBL3901896 — EC50 = 250.0 nM 6.60