Assay Detail
Binding
CHEMBL4420028
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of aldehyde oxidase in human liver cytosolic fraction using methyl-nicotinamide substrate incubated for 120 mins by HPLC analysis
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Tissue | Liver |
| Subcellular | Cytosolic Fraction |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Therapeutic agent for nonalcoholic fatty liver disease
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 4.86 | 7.35 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL81 | RALOXIFENE | 4.0 | 1 | 7.35 |
| CHEMBL276832 | HYDRALAZINE | 4.0 | 1 | 5.41 |
| CHEMBL42 | CLOZAPINE | 4.0 | 1 | 4.36 |
| CHEMBL532 | ERYTHROMYCIN | 4.0 | 1 | 4.01 |
| CHEMBL83 | TAMOXIFEN | 4.0 | 1 | 4.01 |
| CHEMBL590 | MENADIONE | 4.0 | 1 | 4.00 |
| CHEMBL259898 | PRASTERONE SULFURIC ACID | -1.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL81 | RALOXIFENE | IC50 | = | 44.5 | nM | 7.35 |
| CHEMBL276832 | HYDRALAZINE | IC50 | = | 3930.0 | nM | 5.41 |
| CHEMBL42 | CLOZAPINE | IC50 | = | 43300.0 | nM | 4.36 |
| CHEMBL532 | ERYTHROMYCIN | IC50 | = | 96900.0 | nM | 4.01 |
| CHEMBL83 | TAMOXIFEN | IC50 | = | 97300.0 | nM | 4.01 |
| CHEMBL590 | MENADIONE | IC50 | = | 99200.0 | nM | 4.00 |
| CHEMBL259898 | PRASTERONE SULFURIC ACID | IC50 | > | 100000.0 | nM | - |