Assay Detail
Binding
CHEMBL4420247
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of RPE65 in bovine RPE microsomes assessed as reduction in isomero-hydrolase activity using all-trans-[3H]-retinol by normal phase HPLC with flow scintillation analysis
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Bos taurus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Compositions and methods of inhibiting retinal degeneration
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 4.15 | 4.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4460257 | — | — | 1 | 4.30 |
| CHEMBL4526803 | — | — | 1 | 4.22 |
| CHEMBL4563763 | — | — | 1 | 4.22 |
| CHEMBL13210 | — | — | 1 | 4.00 |
| CHEMBL539219 | — | — | 1 | 4.00 |
| CHEMBL4456172 | — | — | 1 | - |
| CHEMBL4561265 | — | — | 1 | - |
| CHEMBL4468736 | — | — | 1 | - |
| CHEMBL4554552 | — | — | 1 | - |
| CHEMBL4445639 | — | — | 1 | - |
| CHEMBL4475224 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4460257 | — | IC50 | = | 50000.0 | nM | 4.30 |
| CHEMBL4526803 | — | IC50 | = | 60000.0 | nM | 4.22 |
| CHEMBL4563763 | — | IC50 | = | 60000.0 | nM | 4.22 |
| CHEMBL13210 | — | IC50 | = | 100000.0 | nM | 4.00 |
| CHEMBL539219 | — | IC50 | = | 100000.0 | nM | 4.00 |
| CHEMBL4456172 | — | IC50 | = | 500000.0 | nM | - |
| CHEMBL4561265 | — | IC50 | > | 2000000.0 | nM | - |
| CHEMBL4468736 | — | IC50 | = | 1300000.0 | nM | - |
| CHEMBL4554552 | — | IC50 | = | 280000.0 | nM | - |
| CHEMBL4445639 | — | IC50 | = | 500000.0 | nM | - |
| CHEMBL4475224 | — | IC50 | > | 3000000.0 | nM | - |