Assay Detail
Binding
CHEMBL4420280
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of TFPI in human plasma with induced factor-8 deficiency assessed as increase in thrombin generation by measuring FEIBA using thrombin-specific fluorogenic substrate Z-Gly-Gly-Arg-AMC by calibrated automated thrombography
44
Total Activities
44
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Tissue | Plasma |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Tfpi inhibitors and methods of use
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 44 | 6.04 | 6.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3958046 | — | — | 1 | 6.96 |
| CHEMBL3930464 | — | — | 1 | 6.92 |
| CHEMBL4545754 | — | — | 1 | 6.89 |
| CHEMBL3894172 | — | — | 1 | 6.80 |
| CHEMBL3935596 | — | — | 1 | 6.77 |
| CHEMBL3960763 | — | — | 1 | 6.68 |
| CHEMBL3891294 | — | — | 1 | 6.58 |
| CHEMBL3974158 | — | — | 1 | 6.58 |
| CHEMBL4543933 | — | — | 1 | 6.54 |
| CHEMBL3975755 | — | — | 1 | 6.50 |
| CHEMBL4446952 | — | — | 1 | 6.38 |
| CHEMBL3932312 | — | — | 1 | 6.33 |
| CHEMBL4448151 | — | — | 1 | 6.24 |
| CHEMBL4447278 | — | — | 1 | 6.20 |
| CHEMBL4529374 | — | — | 1 | 6.11 |
| CHEMBL4473601 | — | — | 1 | 6.09 |
| CHEMBL4443384 | — | — | 1 | 6.07 |
| CHEMBL3955549 | — | — | 1 | 6.07 |
| CHEMBL3912278 | — | — | 1 | 6.05 |
| CHEMBL4475522 | — | — | 1 | 6.05 |
| CHEMBL4449783 | — | — | 1 | 6.03 |
| CHEMBL4547511 | — | — | 1 | 6.02 |
| CHEMBL4444694 | — | — | 1 | 5.97 |
| CHEMBL4473322 | — | — | 1 | 5.96 |
| CHEMBL4454557 | — | — | 1 | 5.93 |
| CHEMBL4454621 | — | — | 1 | 5.89 |
| CHEMBL4452013 | — | — | 1 | 5.86 |
| CHEMBL4452653 | — | — | 1 | 5.84 |
| CHEMBL4548910 | — | — | 1 | 5.83 |
| CHEMBL4519206 | — | — | 1 | 5.82 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3958046 | — | EC50 | = | 110.0 | nM | 6.96 |
| CHEMBL3930464 | — | EC50 | = | 120.0 | nM | 6.92 |
| CHEMBL4545754 | — | EC50 | = | 130.0 | nM | 6.89 |
| CHEMBL3894172 | — | EC50 | = | 160.0 | nM | 6.80 |
| CHEMBL3935596 | — | EC50 | = | 170.0 | nM | 6.77 |
| CHEMBL3960763 | — | EC50 | = | 210.0 | nM | 6.68 |
| CHEMBL3891294 | — | EC50 | = | 260.0 | nM | 6.58 |
| CHEMBL3974158 | — | EC50 | = | 260.0 | nM | 6.58 |
| CHEMBL4543933 | — | EC50 | = | 290.0 | nM | 6.54 |
| CHEMBL3975755 | — | EC50 | = | 320.0 | nM | 6.50 |
| CHEMBL4446952 | — | EC50 | = | 420.0 | nM | 6.38 |
| CHEMBL3932312 | — | EC50 | = | 470.0 | nM | 6.33 |
| CHEMBL4448151 | — | EC50 | = | 570.0 | nM | 6.24 |
| CHEMBL4447278 | — | EC50 | = | 630.0 | nM | 6.20 |
| CHEMBL4529374 | — | EC50 | = | 770.0 | nM | 6.11 |
| CHEMBL4473601 | — | EC50 | = | 820.0 | nM | 6.09 |
| CHEMBL4443384 | — | EC50 | = | 850.0 | nM | 6.07 |
| CHEMBL3955549 | — | EC50 | = | 850.0 | nM | 6.07 |
| CHEMBL3912278 | — | EC50 | = | 890.0 | nM | 6.05 |
| CHEMBL4475522 | — | EC50 | = | 890.0 | nM | 6.05 |
| CHEMBL4449783 | — | EC50 | = | 940.0 | nM | 6.03 |
| CHEMBL4547511 | — | EC50 | = | 950.0 | nM | 6.02 |
| CHEMBL4444694 | — | EC50 | = | 1060.0 | nM | 5.97 |
| CHEMBL4473322 | — | EC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL4454557 | — | EC50 | = | 1170.0 | nM | 5.93 |
| CHEMBL4454621 | — | EC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL4452013 | — | EC50 | = | 1380.0 | nM | 5.86 |
| CHEMBL4452653 | — | EC50 | = | 1450.0 | nM | 5.84 |
| CHEMBL4548910 | — | EC50 | = | 1480.0 | nM | 5.83 |
| CHEMBL4519206 | — | EC50 | = | 1530.0 | nM | 5.82 |
| CHEMBL4461969 | — | EC50 | = | 1550.0 | nM | 5.81 |
| CHEMBL3910529 | — | EC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL4449463 | — | EC50 | = | 1630.0 | nM | 5.79 |
| CHEMBL4517694 | — | EC50 | = | 1750.0 | nM | 5.76 |
| CHEMBL4458443 | — | EC50 | = | 2460.0 | nM | 5.61 |
| CHEMBL4545704 | — | EC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL4436238 | — | EC50 | = | 2540.0 | nM | 5.59 |
| CHEMBL4471068 | — | EC50 | = | 2780.0 | nM | 5.56 |
| CHEMBL4539699 | — | EC50 | = | 2990.0 | nM | 5.52 |
| CHEMBL4456248 | — | EC50 | = | 3100.0 | nM | 5.51 |
| CHEMBL4448999 | — | EC50 | = | 3150.0 | nM | 5.50 |
| CHEMBL4440205 | — | EC50 | = | 3800.0 | nM | 5.42 |
| CHEMBL4442429 | — | EC50 | = | 4790.0 | nM | 5.32 |
| CHEMBL4440967 | — | EC50 | = | 7920.0 | nM | 5.10 |