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Assay Detail

CHEMBL4420282

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Binding affinity to TFPI (unknown origin) incubated for 1.5 hrs using tracer peptide JBT0131 by screening ELISA
ChEMBL ↗
1632
Total Activities
1632
Compounds Tested
2
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Tissue factor pathway inhibitor (CHEMBL3713062) ↗
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Tfpi inhibitors and methods of use
(2013)

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 1629 6.53 8.79
Ki 3 5.30 5.30

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL4588428 — — 1 8.79
CHEMBL4442890 — — 1 8.71
CHEMBL4462279 — — 1 8.71
CHEMBL4434734 — — 1 8.70
CHEMBL4454494 — — 1 8.69
CHEMBL4576960 — — 1 8.69
CHEMBL4548599 — — 1 8.65
CHEMBL4524770 — — 1 8.63
CHEMBL4589534 — — 1 8.61
CHEMBL4575950 — — 1 8.60
CHEMBL4473539 — — 1 8.58
CHEMBL4455635 — — 1 8.57
CHEMBL4536931 — — 1 8.56
CHEMBL4541662 — — 1 8.56
CHEMBL4435272 — — 1 8.56
CHEMBL4548806 — — 1 8.55
CHEMBL4545581 — — 1 8.54
CHEMBL4444941 — — 1 8.53
CHEMBL4460619 — — 1 8.52
CHEMBL4444069 — — 1 8.52
CHEMBL4519571 — — 1 8.52
CHEMBL4466002 — — 1 8.52
CHEMBL4551196 — — 1 8.51
CHEMBL4576748 — — 1 8.50
CHEMBL4551544 — — 1 8.49
CHEMBL4455306 — — 1 8.48
CHEMBL4454430 — — 1 8.47
CHEMBL4553061 — — 1 8.47
CHEMBL4588058 — — 1 8.47
CHEMBL4519075 — — 1 8.46

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL4588428 — IC50 = 1.63 nM 8.79
CHEMBL4462279 — IC50 = 1.94 nM 8.71
CHEMBL4442890 — IC50 = 1.94 nM 8.71
CHEMBL4434734 — IC50 = 1.99 nM 8.70
CHEMBL4576960 — IC50 = 2.05 nM 8.69
CHEMBL4454494 — IC50 = 2.03 nM 8.69
CHEMBL4548599 — IC50 = 2.22 nM 8.65
CHEMBL4524770 — IC50 = 2.32 nM 8.63
CHEMBL4589534 — IC50 = 2.44 nM 8.61
CHEMBL4575950 — IC50 = 2.49 nM 8.60
CHEMBL4473539 — IC50 = 2.62 nM 8.58
CHEMBL4455635 — IC50 = 2.7 nM 8.57
CHEMBL4541662 — IC50 = 2.75 nM 8.56
CHEMBL4435272 — IC50 = 2.74 nM 8.56
CHEMBL4536931 — IC50 = 2.72 nM 8.56
CHEMBL4548806 — IC50 = 2.84 nM 8.55
CHEMBL4545581 — IC50 = 2.91 nM 8.54
CHEMBL4444941 — IC50 = 2.97 nM 8.53
CHEMBL4460619 — IC50 = 3.05 nM 8.52
CHEMBL4519571 — IC50 = 3.04 nM 8.52
CHEMBL4466002 — IC50 = 3.01 nM 8.52
CHEMBL4444069 — IC50 = 3.04 nM 8.52
CHEMBL4551196 — IC50 = 3.12 nM 8.51
CHEMBL4576748 — IC50 = 3.13 nM 8.50
CHEMBL4551544 — IC50 = 3.23 nM 8.49
CHEMBL4455306 — IC50 = 3.27 nM 8.48
CHEMBL4553061 — IC50 = 3.41 nM 8.47
CHEMBL4588058 — IC50 = 3.36 nM 8.47
CHEMBL4454430 — IC50 = 3.36 nM 8.47
CHEMBL4584119 — IC50 = 3.44 nM 8.46
CHEMBL4519075 — IC50 = 3.45 nM 8.46
CHEMBL4460229 — IC50 = 3.56 nM 8.45
CHEMBL4462029 — IC50 = 3.62 nM 8.44
CHEMBL4460461 — IC50 = 3.76 nM 8.43
CHEMBL4434913 — IC50 = 3.74 nM 8.43
CHEMBL4443786 — IC50 = 3.81 nM 8.42
CHEMBL4557350 — IC50 = 3.78 nM 8.42
CHEMBL4449617 — IC50 = 3.89 nM 8.41
CHEMBL4450444 — IC50 = 3.89 nM 8.41
CHEMBL4441167 — IC50 = 3.86 nM 8.41
CHEMBL4591407 — IC50 = 4.02 nM 8.40
CHEMBL4466545 — IC50 = 3.99 nM 8.40
CHEMBL4537446 — IC50 = 4.07 nM 8.39
CHEMBL4466077 — IC50 = 4.1 nM 8.39
CHEMBL4436719 — IC50 = 4.15 nM 8.38
CHEMBL4462049 — IC50 = 4.23 nM 8.37
CHEMBL4438694 — IC50 = 4.29 nM 8.37
CHEMBL4536895 — IC50 = 4.23 nM 8.37
CHEMBL4546132 — IC50 = 4.37 nM 8.36
CHEMBL4525293 — IC50 = 4.37 nM 8.36