Assay Detail
Binding
CHEMBL4420384
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Binding affinity to TFPI (unknown origin) incubated for 1.5 hrs using 0.5 nM tracer peptide JBT0131 by screening ELISA
38
Total Activities
38
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Tfpi inhibitors and methods of use
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 38 | 8.89 | 9.28 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4473203 | — | — | 1 | 9.28 |
| CHEMBL4447126 | — | — | 1 | 9.25 |
| CHEMBL4544981 | — | — | 1 | 9.24 |
| CHEMBL4515587 | — | — | 1 | 9.24 |
| CHEMBL4467258 | — | — | 1 | 9.24 |
| CHEMBL4570697 | — | — | 1 | 9.22 |
| CHEMBL4450425 | — | — | 1 | 9.21 |
| CHEMBL4517882 | — | — | 1 | 9.21 |
| CHEMBL4470799 | — | — | 1 | 9.19 |
| CHEMBL4476135 | — | — | 1 | 9.19 |
| CHEMBL4555480 | — | — | 1 | 9.18 |
| CHEMBL4449476 | — | — | 1 | 9.18 |
| CHEMBL4443775 | — | — | 1 | 9.15 |
| CHEMBL4556108 | — | — | 1 | 9.14 |
| CHEMBL4463366 | — | — | 1 | 9.14 |
| CHEMBL4574858 | — | — | 1 | 9.13 |
| CHEMBL4439410 | — | — | 1 | 9.11 |
| CHEMBL4527541 | — | — | 1 | 9.06 |
| CHEMBL4515393 | — | — | 1 | 9.06 |
| CHEMBL4448457 | — | — | 1 | 9.04 |
| CHEMBL4475900 | — | — | 1 | 9.03 |
| CHEMBL4581025 | — | — | 1 | 9.02 |
| CHEMBL4476540 | — | — | 1 | 9.00 |
| CHEMBL4563370 | — | — | 1 | 8.98 |
| CHEMBL4513672 | — | — | 1 | 8.97 |
| CHEMBL4451907 | — | — | 1 | 8.94 |
| CHEMBL4593874 | — | — | 1 | 8.91 |
| CHEMBL4436906 | — | — | 1 | 8.88 |
| CHEMBL4529807 | — | — | 1 | 8.87 |
| CHEMBL4440879 | — | — | 1 | 8.79 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4473203 | — | IC50 | = | 0.52 | nM | 9.28 |
| CHEMBL4447126 | — | IC50 | = | 0.56 | nM | 9.25 |
| CHEMBL4515587 | — | IC50 | = | 0.58 | nM | 9.24 |
| CHEMBL4467258 | — | IC50 | = | 0.57 | nM | 9.24 |
| CHEMBL4544981 | — | IC50 | = | 0.57 | nM | 9.24 |
| CHEMBL4570697 | — | IC50 | = | 0.6 | nM | 9.22 |
| CHEMBL4450425 | — | IC50 | = | 0.61 | nM | 9.21 |
| CHEMBL4517882 | — | IC50 | = | 0.61 | nM | 9.21 |
| CHEMBL4470799 | — | IC50 | = | 0.64 | nM | 9.19 |
| CHEMBL4476135 | — | IC50 | = | 0.65 | nM | 9.19 |
| CHEMBL4449476 | — | IC50 | = | 0.66 | nM | 9.18 |
| CHEMBL4555480 | — | IC50 | = | 0.66 | nM | 9.18 |
| CHEMBL4443775 | — | IC50 | = | 0.71 | nM | 9.15 |
| CHEMBL4556108 | — | IC50 | = | 0.72 | nM | 9.14 |
| CHEMBL4463366 | — | IC50 | = | 0.72 | nM | 9.14 |
| CHEMBL4574858 | — | IC50 | = | 0.74 | nM | 9.13 |
| CHEMBL4439410 | — | IC50 | = | 0.78 | nM | 9.11 |
| CHEMBL4527541 | — | IC50 | = | 0.87 | nM | 9.06 |
| CHEMBL4515393 | — | IC50 | = | 0.88 | nM | 9.06 |
| CHEMBL4448457 | — | IC50 | = | 0.92 | nM | 9.04 |
| CHEMBL4475900 | — | IC50 | = | 0.94 | nM | 9.03 |
| CHEMBL4581025 | — | IC50 | = | 0.96 | nM | 9.02 |
| CHEMBL4476540 | — | IC50 | = | 1.01 | nM | 9.00 |
| CHEMBL4563370 | — | IC50 | = | 1.04 | nM | 8.98 |
| CHEMBL4513672 | — | IC50 | = | 1.06 | nM | 8.97 |
| CHEMBL4451907 | — | IC50 | = | 1.14 | nM | 8.94 |
| CHEMBL4593874 | — | IC50 | = | 1.22 | nM | 8.91 |
| CHEMBL4436906 | — | IC50 | = | 1.32 | nM | 8.88 |
| CHEMBL4529807 | — | IC50 | = | 1.34 | nM | 8.87 |
| CHEMBL4440879 | — | IC50 | = | 1.63 | nM | 8.79 |
| CHEMBL4472115 | — | IC50 | = | 1.75 | nM | 8.76 |
| CHEMBL4520832 | — | IC50 | = | 1.86 | nM | 8.73 |
| CHEMBL4564338 | — | IC50 | = | 2.04 | nM | 8.69 |
| CHEMBL4448017 | — | IC50 | = | 2.06 | nM | 8.69 |
| CHEMBL4443880 | — | IC50 | = | 2.2 | nM | 8.66 |
| CHEMBL4458774 | — | IC50 | = | 7.75 | nM | 8.11 |
| CHEMBL4576533 | — | IC50 | = | 110.47 | nM | 6.96 |
| CHEMBL4448151 | — | IC50 | = | 278.44 | nM | 6.55 |