Assay Detail
Functional
CHEMBL4420449
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Growth inhibition of human NSCLC expressing mutant KRAS assessed as inhibition of 2D cell growth
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | Non-small cell lung cancer cell line |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Compounds, compositions and methods for inhibiting cnksr1
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 15 | 4.67 | 5.17 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4280622 | — | — | 1 | 5.17 |
| CHEMBL4286687 | — | — | 1 | 4.95 |
| CHEMBL4278147 | — | — | 1 | 4.80 |
| CHEMBL4293956 | — | — | 1 | 4.79 |
| CHEMBL4288751 | — | — | 1 | 4.75 |
| CHEMBL4277129 | — | — | 1 | 4.72 |
| CHEMBL4278527 | — | — | 1 | 4.72 |
| CHEMBL4278841 | — | — | 1 | 4.71 |
| CHEMBL4285086 | — | — | 1 | 4.70 |
| CHEMBL4282142 | — | — | 1 | 4.64 |
| CHEMBL4294863 | — | — | 1 | 4.60 |
| CHEMBL4282649 | — | — | 1 | 4.60 |
| CHEMBL4277811 | — | — | 1 | 4.46 |
| CHEMBL4283706 | — | — | 1 | 4.24 |
| CHEMBL4282291 | — | — | 1 | 4.19 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4280622 | — | IC50 | = | 6700.0 | nM | 5.17 |
| CHEMBL4286687 | — | IC50 | = | 11200.0 | nM | 4.95 |
| CHEMBL4278147 | — | IC50 | = | 15700.0 | nM | 4.80 |
| CHEMBL4293956 | — | IC50 | = | 16300.0 | nM | 4.79 |
| CHEMBL4288751 | — | IC50 | = | 18000.0 | nM | 4.75 |
| CHEMBL4277129 | — | IC50 | = | 18900.0 | nM | 4.72 |
| CHEMBL4278527 | — | IC50 | = | 19200.0 | nM | 4.72 |
| CHEMBL4278841 | — | IC50 | = | 19500.0 | nM | 4.71 |
| CHEMBL4285086 | — | IC50 | = | 20000.0 | nM | 4.70 |
| CHEMBL4282142 | — | IC50 | = | 23000.0 | nM | 4.64 |
| CHEMBL4294863 | — | IC50 | = | 25000.0 | nM | 4.60 |
| CHEMBL4282649 | — | IC50 | = | 25000.0 | nM | 4.60 |
| CHEMBL4277811 | — | IC50 | = | 35000.0 | nM | 4.46 |
| CHEMBL4283706 | — | IC50 | = | 57000.0 | nM | 4.24 |
| CHEMBL4282291 | — | IC50 | = | 65000.0 | nM | 4.19 |