Assay Detail
Functional
CHEMBL4420450
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Growth inhibition of human NSCLC expressing mutant KRAS assessed as inhibition of 3D cell growth
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | Non-small cell lung cancer cell line |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Compounds, compositions and methods for inhibiting cnksr1
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 5.66 | 6.57 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4285086 | — | — | 1 | 6.57 |
| CHEMBL4288751 | — | — | 1 | 6.16 |
| CHEMBL4278147 | — | — | 1 | 5.92 |
| CHEMBL4278527 | — | — | 1 | 5.39 |
| CHEMBL4293956 | — | — | 1 | 5.08 |
| CHEMBL4278841 | — | — | 1 | 4.82 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4285086 | — | IC50 | = | 270.0 | nM | 6.57 |
| CHEMBL4288751 | — | IC50 | = | 690.0 | nM | 6.16 |
| CHEMBL4278147 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL4278527 | — | IC50 | = | 4100.0 | nM | 5.39 |
| CHEMBL4293956 | — | IC50 | = | 8400.0 | nM | 5.08 |
| CHEMBL4278841 | — | IC50 | = | 15000.0 | nM | 4.82 |