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Assay Detail

CHEMBL4420562

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Cytotoxicity against human NCI-H1703 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
21
Total Activities
21
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type NCI-H1703
Confidence 1 — Organism
Curated By Autocuration

Target

NCI-H1703 (CHEMBL1075522)
Type CELL-LINE
Organism Homo sapiens

Publication

Aryl amine substituted quinoxaline used as anticancer drugs
(2017)

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 21 6.20 7.70

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL4466157 1 7.70
CHEMBL4559219 1 7.00
CHEMBL4463884 1 7.00
CHEMBL4534395 1 7.00
CHEMBL4524916 1 7.00
CHEMBL4448241 1 6.70
CHEMBL3604526 1 6.52
CHEMBL4584915 1 6.52
CHEMBL4517484 1 6.40
CHEMBL4551394 1 6.30
CHEMBL4458957 1 6.22
CHEMBL4533267 1 6.05
CHEMBL4470413 1 6.00
CHEMBL4470283 1 5.92
CHEMBL4468709 1 5.89
CHEMBL4460989 1 5.42
CHEMBL4531564 1 5.13
CHEMBL4570486 1 5.13
CHEMBL4463097 1 5.08
CHEMBL4538930 1 5.07
CHEMBL4530298 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL4466157 IC50 = 20.0 nM 7.70
CHEMBL4559219 IC50 = 100.0 nM 7.00
CHEMBL4463884 IC50 = 100.0 nM 7.00
CHEMBL4534395 IC50 = 100.0 nM 7.00
CHEMBL4524916 IC50 = 100.0 nM 7.00
CHEMBL4448241 IC50 = 200.0 nM 6.70
CHEMBL3604526 IC50 = 300.0 nM 6.52
CHEMBL4584915 IC50 = 300.0 nM 6.52
CHEMBL4517484 IC50 = 400.0 nM 6.40
CHEMBL4551394 IC50 = 500.0 nM 6.30
CHEMBL4458957 IC50 = 600.0 nM 6.22
CHEMBL4533267 IC50 = 900.0 nM 6.05
CHEMBL4470413 IC50 = 1000.0 nM 6.00
CHEMBL4470283 IC50 = 1200.0 nM 5.92
CHEMBL4468709 IC50 = 1300.0 nM 5.89
CHEMBL4460989 IC50 = 3800.0 nM 5.42
CHEMBL4531564 IC50 = 7400.0 nM 5.13
CHEMBL4570486 IC50 = 7400.0 nM 5.13
CHEMBL4463097 IC50 = 8300.0 nM 5.08
CHEMBL4538930 IC50 = 8600.0 nM 5.07
CHEMBL4530298 IC50 > 10000.0 nM -