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Compound Detail

CHEMBL4463097

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c1ccc(Nc2nc3ccccc3nc2Nc2ccccc2)cc1

Basic Information

ChEMBL ID CHEMBL4463097
Phase Preclinical
Structure Type MOL
InChI Key DUNUJOGNOJENGT-UHFFFAOYSA-N
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
0
Publications
0
Known Names

Molecular Properties

312.4
MW (Da)
5.12
ALogP
4
HBA
2
HBD
49.8
PSA (Ų)
0.55
QED
1
Ro5 Violations
4
Rot. Bonds

Drug Information

Molecule Type Unknown
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C20H16N4
MW 312.38
Aromatic Rings 4
Heavy Atoms 24
NP-Likeness -0.77

Activity Summary

IC50 1 meas. best 5.08

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
NCI-H1703
CHEMBL1075522
IC50 5.08 5.08 8300.0 1

Activity Data Samples

Top measurements by pChEMBL value

Target Type Rel. Value Units pChEMBL Assay PubMed
NCI-H1703 IC50 = 8300.0 nM 5.08 Cytotoxicity against human NCI-H1703 cells assessed as reduction in cell viabili... -

Data from ChEMBL 36 via Core Engine