Assay Detail
Binding
CHEMBL4420663
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human LATS1 kinase domain (589 to 1130 amino acids) incubated for 1 hr in presence of Fluo-SGKtide substrate by fluorescence detection based biochemical caliper assay
45
Total Activities
45
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Serine/threonine-protein kinase LATS1 (CHEMBL6167) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
6-6 Fused Bicyclic Heteroaryl Compounds and their Use as LATS Inhibitors
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 45 | 7.86 | 9.15 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4439972 | — | — | 1 | 9.15 |
| CHEMBL4447153 | — | — | 1 | 9.10 |
| CHEMBL4525078 | — | — | 1 | 9.10 |
| CHEMBL4446217 | — | — | 1 | 8.92 |
| CHEMBL4590309 | — | — | 1 | 8.92 |
| CHEMBL4456826 | — | — | 1 | 8.74 |
| CHEMBL4483764 | — | — | 1 | 8.72 |
| CHEMBL4476463 | — | — | 1 | 8.64 |
| CHEMBL3338837 | — | — | 1 | 8.62 |
| CHEMBL4465820 | — | — | 1 | 8.52 |
| CHEMBL4436919 | — | — | 1 | 8.51 |
| CHEMBL4439805 | — | — | 1 | 8.43 |
| CHEMBL4476521 | — | — | 1 | 8.42 |
| CHEMBL2147535 | — | — | 1 | 8.42 |
| CHEMBL4468766 | — | — | 1 | 8.35 |
| CHEMBL4464441 | — | — | 1 | 8.35 |
| CHEMBL4472021 | — | — | 1 | 8.30 |
| CHEMBL4563473 | — | — | 1 | 8.28 |
| CHEMBL4566594 | — | — | 1 | 8.21 |
| CHEMBL4459788 | — | — | 1 | 8.12 |
| CHEMBL4566901 | — | — | 1 | 8.12 |
| CHEMBL4448408 | — | — | 1 | 8.02 |
| CHEMBL4440342 | — | — | 1 | 8.00 |
| CHEMBL4463799 | — | — | 1 | 7.99 |
| CHEMBL4448628 | — | — | 1 | 7.98 |
| CHEMBL4461790 | — | — | 1 | 7.98 |
| CHEMBL4448179 | — | — | 1 | 7.80 |
| CHEMBL4566717 | — | — | 1 | 7.72 |
| CHEMBL4565212 | — | — | 1 | 7.54 |
| CHEMBL4565547 | — | — | 1 | 7.37 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4439972 | — | IC50 | = | 0.7 | nM | 9.15 |
| CHEMBL4447153 | — | IC50 | = | 0.8 | nM | 9.10 |
| CHEMBL4525078 | — | IC50 | = | 0.8 | nM | 9.10 |
| CHEMBL4446217 | — | IC50 | = | 1.2 | nM | 8.92 |
| CHEMBL4590309 | — | IC50 | = | 1.2 | nM | 8.92 |
| CHEMBL4456826 | — | IC50 | = | 1.8 | nM | 8.74 |
| CHEMBL4483764 | — | IC50 | = | 1.9 | nM | 8.72 |
| CHEMBL4476463 | — | IC50 | = | 2.3 | nM | 8.64 |
| CHEMBL3338837 | — | IC50 | = | 2.4 | nM | 8.62 |
| CHEMBL4465820 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL4436919 | — | IC50 | = | 3.1 | nM | 8.51 |
| CHEMBL4439805 | — | IC50 | = | 3.7 | nM | 8.43 |
| CHEMBL4476521 | — | IC50 | = | 3.8 | nM | 8.42 |
| CHEMBL2147535 | — | IC50 | = | 3.8 | nM | 8.42 |
| CHEMBL4464441 | — | IC50 | = | 4.5 | nM | 8.35 |
| CHEMBL4468766 | — | IC50 | = | 4.5 | nM | 8.35 |
| CHEMBL4472021 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL4563473 | — | IC50 | = | 5.2 | nM | 8.28 |
| CHEMBL4566594 | — | IC50 | = | 6.1 | nM | 8.21 |
| CHEMBL4459788 | — | IC50 | = | 7.6 | nM | 8.12 |
| CHEMBL4566901 | — | IC50 | = | 7.5 | nM | 8.12 |
| CHEMBL4448408 | — | IC50 | = | 9.6 | nM | 8.02 |
| CHEMBL4440342 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL4463799 | — | IC50 | = | 10.2 | nM | 7.99 |
| CHEMBL4448628 | — | IC50 | = | 10.4 | nM | 7.98 |
| CHEMBL4461790 | — | IC50 | = | 10.5 | nM | 7.98 |
| CHEMBL4448179 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL4566717 | — | IC50 | = | 18.9 | nM | 7.72 |
| CHEMBL4565212 | — | IC50 | = | 29.2 | nM | 7.54 |
| CHEMBL4565547 | — | IC50 | = | 42.5 | nM | 7.37 |
| CHEMBL4461247 | — | IC50 | = | 43.3 | nM | 7.36 |
| CHEMBL4549171 | — | IC50 | = | 58.1 | nM | 7.24 |
| CHEMBL4457273 | — | IC50 | = | 57.2 | nM | 7.24 |
| CHEMBL4577411 | — | IC50 | = | 59.0 | nM | 7.23 |
| CHEMBL4522691 | — | IC50 | = | 59.5 | nM | 7.22 |
| CHEMBL4556611 | — | IC50 | = | 68.7 | nM | 7.16 |
| CHEMBL4464722 | — | IC50 | = | 97.1 | nM | 7.01 |
| CHEMBL4470844 | — | IC50 | = | 125.1 | nM | 6.90 |
| CHEMBL4444841 | — | IC50 | = | 163.9 | nM | 6.79 |
| CHEMBL4483670 | — | IC50 | = | 208.9 | nM | 6.68 |
| CHEMBL4438995 | — | IC50 | = | 457.0 | nM | 6.34 |
| CHEMBL4539019 | — | IC50 | = | 466.7 | nM | 6.33 |
| CHEMBL4551335 | — | IC50 | = | 662.9 | nM | 6.18 |
| CHEMBL4442656 | — | IC50 | = | 1033.6 | nM | 5.99 |
| CHEMBL4527014 | — | IC50 | - | — | - |