Assay Detail
Binding
CHEMBL4420665
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of LATS in human HaCaT cells assessed as reduction in YAP nuclear translocation incubated for 24 hrs
244
Total Activities
244
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HaCaT |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Target
Serine/threonine-protein kinase LATS (CHEMBL4523992) ↗| Type | PROTEIN FAMILY |
| Organism | Homo sapiens |
Publication
6-6 Fused Bicyclic Heteroaryl Compounds and their Use as LATS Inhibitors
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 244 | 5.42 | 6.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4571192 | — | — | 1 | 6.52 |
| CHEMBL4436727 | — | — | 1 | 6.51 |
| CHEMBL4472285 | — | — | 1 | 6.49 |
| CHEMBL4551441 | — | — | 1 | 6.47 |
| CHEMBL4472306 | — | — | 1 | 6.47 |
| CHEMBL4467179 | — | — | 1 | 6.36 |
| CHEMBL4444109 | — | — | 1 | 6.36 |
| CHEMBL4517252 | — | — | 1 | 6.32 |
| CHEMBL4518582 | — | — | 1 | 6.29 |
| CHEMBL4577857 | — | — | 1 | 6.27 |
| CHEMBL4531857 | — | — | 1 | 6.23 |
| CHEMBL4443335 | — | — | 1 | 6.22 |
| CHEMBL4472973 | — | — | 1 | 6.19 |
| CHEMBL4514630 | — | — | 1 | 6.16 |
| CHEMBL4471995 | — | — | 1 | 6.13 |
| CHEMBL4572019 | — | — | 1 | 6.10 |
| CHEMBL4517907 | — | — | 1 | 6.07 |
| CHEMBL4438081 | — | — | 1 | 6.06 |
| CHEMBL4532021 | — | — | 1 | 6.00 |
| CHEMBL4450447 | — | — | 1 | 5.98 |
| CHEMBL4571918 | — | — | 1 | 5.97 |
| CHEMBL4573735 | — | — | 1 | 5.97 |
| CHEMBL4533967 | — | — | 1 | 5.93 |
| CHEMBL4470612 | — | — | 1 | 5.92 |
| CHEMBL4555291 | — | — | 1 | 5.92 |
| CHEMBL4463018 | — | — | 1 | 5.91 |
| CHEMBL4454440 | — | — | 1 | 5.91 |
| CHEMBL4439529 | — | — | 1 | 5.88 |
| CHEMBL4460905 | — | — | 1 | 5.88 |
| CHEMBL4522021 | — | — | 1 | 5.86 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4571192 | — | EC50 | = | 302.0 | nM | 6.52 |
| CHEMBL4436727 | — | EC50 | = | 311.0 | nM | 6.51 |
| CHEMBL4472285 | — | EC50 | = | 326.0 | nM | 6.49 |
| CHEMBL4472306 | — | EC50 | = | 338.0 | nM | 6.47 |
| CHEMBL4551441 | — | EC50 | = | 341.0 | nM | 6.47 |
| CHEMBL4444109 | — | EC50 | = | 438.0 | nM | 6.36 |
| CHEMBL4467179 | — | EC50 | = | 440.0 | nM | 6.36 |
| CHEMBL4517252 | — | EC50 | = | 479.0 | nM | 6.32 |
| CHEMBL4518582 | — | EC50 | = | 517.0 | nM | 6.29 |
| CHEMBL4577857 | — | EC50 | = | 538.0 | nM | 6.27 |
| CHEMBL4531857 | — | EC50 | = | 584.0 | nM | 6.23 |
| CHEMBL4443335 | — | EC50 | = | 606.0 | nM | 6.22 |
| CHEMBL4472973 | — | EC50 | = | 641.0 | nM | 6.19 |
| CHEMBL4514630 | — | EC50 | = | 685.0 | nM | 6.16 |
| CHEMBL4471995 | — | EC50 | = | 733.0 | nM | 6.13 |
| CHEMBL4572019 | — | EC50 | = | 800.0 | nM | 6.10 |
| CHEMBL4517907 | — | EC50 | = | 850.0 | nM | 6.07 |
| CHEMBL4438081 | — | EC50 | = | 873.0 | nM | 6.06 |
| CHEMBL4532021 | — | EC50 | = | 1010.0 | nM | 6.00 |
| CHEMBL4450447 | — | EC50 | = | 1050.0 | nM | 5.98 |
| CHEMBL4573735 | — | EC50 | = | 1070.0 | nM | 5.97 |
| CHEMBL4571918 | — | EC50 | = | 1060.0 | nM | 5.97 |
| CHEMBL4533967 | — | EC50 | = | 1170.0 | nM | 5.93 |
| CHEMBL4470612 | — | EC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL4555291 | — | EC50 | = | 1190.0 | nM | 5.92 |
| CHEMBL4454440 | — | EC50 | = | 1220.0 | nM | 5.91 |
| CHEMBL4463018 | — | EC50 | = | 1220.0 | nM | 5.91 |
| CHEMBL4460905 | — | EC50 | = | 1330.0 | nM | 5.88 |
| CHEMBL4439529 | — | EC50 | = | 1310.0 | nM | 5.88 |
| CHEMBL4522021 | — | EC50 | = | 1390.0 | nM | 5.86 |
| CHEMBL4436873 | — | EC50 | = | 1430.0 | nM | 5.84 |
| CHEMBL4566869 | — | EC50 | = | 1570.0 | nM | 5.80 |
| CHEMBL4585067 | — | EC50 | = | 1670.0 | nM | 5.78 |
| CHEMBL4592930 | — | EC50 | = | 1660.0 | nM | 5.78 |
| CHEMBL4463150 | — | EC50 | = | 1680.0 | nM | 5.78 |
| CHEMBL4471884 | — | EC50 | = | 1680.0 | nM | 5.78 |
| CHEMBL4464251 | — | EC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL4574721 | — | EC50 | = | 1750.0 | nM | 5.76 |
| CHEMBL4547445 | — | EC50 | = | 1990.0 | nM | 5.70 |
| CHEMBL4520049 | — | EC50 | = | 2180.0 | nM | 5.66 |
| CHEMBL4470043 | — | EC50 | = | 2260.0 | nM | 5.65 |
| CHEMBL4436796 | — | EC50 | = | 2270.0 | nM | 5.64 |
| CHEMBL4591428 | — | EC50 | = | 2420.0 | nM | 5.62 |
| CHEMBL4558207 | — | EC50 | = | 2480.0 | nM | 5.61 |
| CHEMBL4592699 | — | EC50 | = | 2530.0 | nM | 5.60 |
| CHEMBL4513243 | — | EC50 | = | 2660.0 | nM | 5.58 |
| CHEMBL4446730 | — | EC50 | = | 2630.0 | nM | 5.58 |
| CHEMBL4576185 | — | EC50 | = | 2700.0 | nM | 5.57 |
| CHEMBL4520021 | — | EC50 | = | 2730.0 | nM | 5.56 |
| CHEMBL4579119 | — | EC50 | = | 2810.0 | nM | 5.55 |