Compound Detail
CHEMBL4514630
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Basic Information
| ChEMBL ID | CHEMBL4514630 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | IJPRRFQGFGXIFM-UHFFFAOYSA-N |
2
Targets
2
Activities
2
Assay Types
0
PK Parameters
0
Publications
0
Known Names
Molecular Properties
349.3
MW (Da)
2.81
ALogP
6
HBA
2
HBD
83.8
PSA (Ų)
0.75
QED
0
Ro5 Violations
4
Rot. Bonds
Drug Information
| Molecule Type | Unknown |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
EC50 1 meas. best 6.16
IC50 1 meas. best 8.7
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Serine/threonine-protein kinase LATS1 CHEMBL6167 | IC50 | 8.7 | 8.7 | 2.0 | 1 |
| Serine/threonine-protein kinase LATS CHEMBL4523992 | EC50 | 6.16 | 6.16 | 685.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Serine/threonine-protein kinase LATS1 | IC50 | = | 2.0 | nM | 8.7 | Inhibition of human LATS1 kinase domain (589 to 1130 amino acids) incubated for ... | - |
| Serine/threonine-protein kinase LATS | EC50 | = | 685.0 | nM | 6.16 | Inhibition of LATS in human HaCaT cells assessed as reduction in YAP nuclear tra... | - |
Data from ChEMBL 36 via Core Engine