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Assay Detail

CHEMBL4421037

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Displacement of [125I]-labeled rat amylin from human amylin receptor expressed in BHK570 cell membranes co-expressing RAMP3 incubated for 120 mins by scintillation proximity assay
ChEMBL ↗
39
Total Activities
39
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 7 — Homologous single protein target
Curated By Autocuration

Target

Amylin receptor AMY3; CALCR/RAMP3 (CHEMBL2111190) ↗
Type PROTEIN COMPLEX
Organism Homo sapiens

Publication

Amylin and calcitonin receptor agonist
(2017)

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 39 9.76 10.82

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL4560310 — — 1 10.82
CHEMBL4540155 — — 1 10.54
CHEMBL4557924 — — 1 10.43
CHEMBL4438518 — — 1 10.30
CHEMBL4450293 — — 1 10.27
CHEMBL4514098 — — 1 10.24
CHEMBL4572775 — — 1 10.13
CHEMBL4580170 — — 1 10.11
CHEMBL4439140 — — 1 9.94
CHEMBL4585550 — — 1 9.91
CHEMBL4471035 — — 1 9.91
CHEMBL4583510 — — 1 9.88
CHEMBL4584790 — — 1 9.85
CHEMBL4570633 — — 1 9.85
CHEMBL4444482 — — 1 9.82
CHEMBL4544971 — — 1 9.80
CHEMBL4446788 — — 1 9.80
CHEMBL4519563 — — 1 9.79
CHEMBL4473873 — — 1 9.78
CHEMBL4567286 — — 1 9.78
CHEMBL4573370 — — 1 9.77
CHEMBL4451330 — — 1 9.70
CHEMBL4436860 — — 1 9.69
CHEMBL4568742 — — 1 9.67
CHEMBL4456679 — — 1 9.65
CHEMBL4557587 — — 1 9.61
CHEMBL4529360 — — 1 9.60
CHEMBL4469301 — — 1 9.53
CHEMBL4454002 — — 1 9.51
CHEMBL4580205 — — 1 9.43

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL4560310 — IC50 = 0.015 nM 10.82
CHEMBL4540155 — IC50 = 0.029 nM 10.54
CHEMBL4557924 — IC50 = 0.037 nM 10.43
CHEMBL4438518 — IC50 = 0.05 nM 10.30
CHEMBL4450293 — IC50 = 0.054 nM 10.27
CHEMBL4514098 — IC50 = 0.057 nM 10.24
CHEMBL4572775 — IC50 = 0.074 nM 10.13
CHEMBL4580170 — IC50 = 0.077 nM 10.11
CHEMBL4439140 — IC50 = 0.114 nM 9.94
CHEMBL4471035 — IC50 = 0.124 nM 9.91
CHEMBL4585550 — IC50 = 0.122 nM 9.91
CHEMBL4583510 — IC50 = 0.131 nM 9.88
CHEMBL4584790 — IC50 = 0.141 nM 9.85
CHEMBL4570633 — IC50 = 0.141 nM 9.85
CHEMBL4444482 — IC50 = 0.152 nM 9.82
CHEMBL4544971 — IC50 = 0.159 nM 9.80
CHEMBL4446788 — IC50 = 0.159 nM 9.80
CHEMBL4519563 — IC50 = 0.164 nM 9.79
CHEMBL4567286 — IC50 = 0.166 nM 9.78
CHEMBL4473873 — IC50 = 0.166 nM 9.78
CHEMBL4573370 — IC50 = 0.171 nM 9.77
CHEMBL4451330 — IC50 = 0.202 nM 9.70
CHEMBL4436860 — IC50 = 0.206 nM 9.69
CHEMBL4568742 — IC50 = 0.216 nM 9.67
CHEMBL4456679 — IC50 = 0.225 nM 9.65
CHEMBL4557587 — IC50 = 0.243 nM 9.61
CHEMBL4529360 — IC50 = 0.251 nM 9.60
CHEMBL4469301 — IC50 = 0.297 nM 9.53
CHEMBL4454002 — IC50 = 0.309 nM 9.51
CHEMBL4580205 — IC50 = 0.371 nM 9.43
CHEMBL4474371 — IC50 = 0.39 nM 9.41
CHEMBL4475352 — IC50 = 0.389 nM 9.41
CHEMBL4443697 — IC50 = 0.394 nM 9.40
CHEMBL4453619 — IC50 = 0.442 nM 9.36
CHEMBL4443487 — IC50 = 0.516 nM 9.29
CHEMBL4463230 — IC50 = 0.565 nM 9.25
CHEMBL4466125 — IC50 = 0.724 nM 9.14
CHEMBL4575327 — IC50 = 0.72 nM 9.14
CHEMBL4535261 — IC50 = 0.773 nM 9.11