Compound Detail

CHEMBL4535261

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ChEMBL ↗ Properties Compare Identifier

Basic Information

ChEMBL ID	CHEMBL4535261
Phase	Preclinical
Structure Type	MOL
InChI Key	XAJWNQQOWPXVLA-FRQVSACESA-N

Targets

Activities

Assay Types

PK Parameters

Publications

Known Names

Molecular Properties

3462.9

MW (Da)

Drug Information

Molecule Type	Unknown
Availability	Unknown
Chirality	Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula	C150H253N41O52
MW	3462.91

Activity Summary

EC50 4 meas.

IC50 3 meas. best 9.91

Target Activity Profile

Target	Type	Best pChEMBL	Mean pChEMBL	Best (nM)	# Data
Calcitonin receptor CHEMBL1832	IC50	9.91	9.88	0.1	2
Amylin receptor AMY3; CALCR/RAMP3 CHEMBL2111190	IC50	9.11	9.11	0.8	1

Activity Data Samples

Top measurements by pChEMBL value

Target	Type	Rel.	Value	Units	pChEMBL	Assay	PubMed
Calcitonin receptor	IC50	=	0.123	nM	9.91	Displacement of [125I]-labeled rat calcitonin from human calcitonin receptor exp...	-
Calcitonin receptor	IC50	=	0.14	nM	9.85	Displacement of [125I]-labeled human calcitonin from human calcitonin receptor e...	-
Amylin receptor AMY3; CALCR/RAMP3	IC50	=	0.773	nM	9.11	Displacement of [125I]-labeled rat amylin from human amylin receptor expressed i...	-

Data from ChEMBL 36 via Core Engine