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Assay Detail

CHEMBL4421040

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Displacement of [125I]-labeled rat calcitonin from human calcitonin receptor expressed in BHK tkts13 cell membranes incubated for 1 hr by scintillation proximity assay
ChEMBL ↗
39
Total Activities
39
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Calcitonin receptor (CHEMBL1832) ↗
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Amylin and calcitonin receptor agonist
(2017)

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 39 10.45 11.00

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL4438518 — — 1 11.00
CHEMBL4560310 — — 1 10.96
CHEMBL4583510 — — 1 10.92
CHEMBL4557924 — — 1 10.89
CHEMBL4580170 — — 1 10.89
CHEMBL4585550 — — 1 10.89
CHEMBL4444482 — — 1 10.80
CHEMBL4450293 — — 1 10.77
CHEMBL4540155 — — 1 10.77
CHEMBL4514098 — — 1 10.70
CHEMBL4469301 — — 1 10.68
CHEMBL4557587 — — 1 10.64
CHEMBL4473873 — — 1 10.57
CHEMBL4451330 — — 1 10.57
CHEMBL4568742 — — 1 10.55
CHEMBL4567286 — — 1 10.51
CHEMBL4456679 — — 1 10.51
CHEMBL4529360 — — 1 10.51
CHEMBL4580205 — — 1 10.49
CHEMBL4584790 — — 1 10.41
CHEMBL4572775 — — 1 10.38
CHEMBL4570633 — — 1 10.36
CHEMBL4471035 — — 1 10.36
CHEMBL4453619 — — 1 10.36
CHEMBL4573370 — — 1 10.21
CHEMBL4439140 — — 1 10.19
CHEMBL4474371 — — 1 10.16
CHEMBL4544971 — — 1 10.16
CHEMBL4436860 — — 1 10.15
CHEMBL4454002 — — 1 10.14

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL4438518 — IC50 = 0.01 nM 11.00
CHEMBL4560310 — IC50 = 0.011 nM 10.96
CHEMBL4583510 — IC50 = 0.012 nM 10.92
CHEMBL4557924 — IC50 = 0.013 nM 10.89
CHEMBL4580170 — IC50 = 0.013 nM 10.89
CHEMBL4585550 — IC50 = 0.013 nM 10.89
CHEMBL4444482 — IC50 = 0.016 nM 10.80
CHEMBL4540155 — IC50 = 0.017 nM 10.77
CHEMBL4450293 — IC50 = 0.017 nM 10.77
CHEMBL4514098 — IC50 = 0.02 nM 10.70
CHEMBL4469301 — IC50 = 0.021 nM 10.68
CHEMBL4557587 — IC50 = 0.023 nM 10.64
CHEMBL4473873 — IC50 = 0.027 nM 10.57
CHEMBL4451330 — IC50 = 0.027 nM 10.57
CHEMBL4568742 — IC50 = 0.028 nM 10.55
CHEMBL4567286 — IC50 = 0.031 nM 10.51
CHEMBL4529360 — IC50 = 0.031 nM 10.51
CHEMBL4456679 — IC50 = 0.031 nM 10.51
CHEMBL4580205 — IC50 = 0.032 nM 10.49
CHEMBL4584790 — IC50 = 0.039 nM 10.41
CHEMBL4572775 — IC50 = 0.042 nM 10.38
CHEMBL4570633 — IC50 = 0.044 nM 10.36
CHEMBL4471035 — IC50 = 0.044 nM 10.36
CHEMBL4453619 — IC50 = 0.044 nM 10.36
CHEMBL4573370 — IC50 = 0.062 nM 10.21
CHEMBL4439140 — IC50 = 0.065 nM 10.19
CHEMBL4474371 — IC50 = 0.069 nM 10.16
CHEMBL4544971 — IC50 = 0.069 nM 10.16
CHEMBL4436860 — IC50 = 0.071 nM 10.15
CHEMBL4454002 — IC50 = 0.072 nM 10.14
CHEMBL4463230 — IC50 = 0.085 nM 10.07
CHEMBL4466125 — IC50 = 0.114 nM 9.94
CHEMBL4535261 — IC50 = 0.123 nM 9.91
CHEMBL4443697 — IC50 = 0.202 nM 9.70
CHEMBL4575327 — IC50 = 0.246 nM 9.61
CHEMBL4443487 — IC50 - — -
CHEMBL4475352 — IC50 - — -
CHEMBL4519563 — IC50 - — -
CHEMBL4446788 — IC50 - — -