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Assay Detail

CHEMBL4421039

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Displacement of [125I]-labeled rat amylin from rat amylin receptor expressed in BHK tkts13 cell membranes co-expressing RAMP3 incubated for 120 mins by scintillation proximity assay
ChEMBL ↗
39
Total Activities
39
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Rattus norvegicus
Confidence 7 — Homologous single protein target
Curated By Autocuration

Target

Amylin receptor AMY3; CALCR/RAMP3 (CHEMBL2109235) ↗
Type PROTEIN COMPLEX
Organism Rattus norvegicus

Publication

Amylin and calcitonin receptor agonist
(2017)

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 39 9.94 10.89

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL4585550 — — 1 10.89
CHEMBL4540155 — — 1 10.77
CHEMBL4557924 — — 1 10.66
CHEMBL4471035 — — 1 10.60
CHEMBL4584790 — — 1 10.59
CHEMBL4567286 — — 1 10.59
CHEMBL4473873 — — 1 10.54
CHEMBL4557587 — — 1 10.54
CHEMBL4544971 — — 1 10.35
CHEMBL4573370 — — 1 10.34
CHEMBL4438518 — — 1 10.34
CHEMBL4514098 — — 1 10.34
CHEMBL4444482 — — 1 10.28
CHEMBL4580170 — — 1 10.20
CHEMBL4560310 — — 1 10.19
CHEMBL4583510 — — 1 10.11
CHEMBL4456679 — — 1 10.04
CHEMBL4568742 — — 1 10.01
CHEMBL4572775 — — 1 9.94
CHEMBL4450293 — — 1 9.91
CHEMBL4469301 — — 1 9.84
CHEMBL4570633 — — 1 9.84
CHEMBL4454002 — — 1 9.79
CHEMBL4451330 — — 1 9.62
CHEMBL4580205 — — 1 9.45
CHEMBL4529360 — — 1 9.43
CHEMBL4575327 — — 1 9.41
CHEMBL4453619 — — 1 9.34
CHEMBL4436860 — — 1 9.16
CHEMBL4474371 — — 1 8.94

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL4585550 — IC50 = 0.013 nM 10.89
CHEMBL4540155 — IC50 = 0.017 nM 10.77
CHEMBL4557924 — IC50 = 0.022 nM 10.66
CHEMBL4471035 — IC50 = 0.025 nM 10.60
CHEMBL4584790 — IC50 = 0.026 nM 10.59
CHEMBL4567286 — IC50 = 0.026 nM 10.59
CHEMBL4473873 — IC50 = 0.029 nM 10.54
CHEMBL4557587 — IC50 = 0.029 nM 10.54
CHEMBL4544971 — IC50 = 0.045 nM 10.35
CHEMBL4514098 — IC50 = 0.046 nM 10.34
CHEMBL4438518 — IC50 = 0.046 nM 10.34
CHEMBL4573370 — IC50 = 0.046 nM 10.34
CHEMBL4444482 — IC50 = 0.053 nM 10.28
CHEMBL4580170 — IC50 = 0.063 nM 10.20
CHEMBL4560310 — IC50 = 0.064 nM 10.19
CHEMBL4583510 — IC50 = 0.078 nM 10.11
CHEMBL4456679 — IC50 = 0.091 nM 10.04
CHEMBL4568742 — IC50 = 0.098 nM 10.01
CHEMBL4572775 — IC50 = 0.115 nM 9.94
CHEMBL4450293 — IC50 = 0.122 nM 9.91
CHEMBL4570633 — IC50 = 0.146 nM 9.84
CHEMBL4469301 — IC50 = 0.146 nM 9.84
CHEMBL4454002 — IC50 = 0.162 nM 9.79
CHEMBL4451330 — IC50 = 0.242 nM 9.62
CHEMBL4580205 — IC50 = 0.357 nM 9.45
CHEMBL4529360 — IC50 = 0.374 nM 9.43
CHEMBL4575327 — IC50 = 0.385 nM 9.41
CHEMBL4453619 — IC50 = 0.455 nM 9.34
CHEMBL4436860 — IC50 = 0.684 nM 9.16
CHEMBL4474371 — IC50 = 1.159 nM 8.94
CHEMBL4439140 — IC50 = 1.302 nM 8.88
CHEMBL4463230 — IC50 = 1.529 nM 8.82
CHEMBL4443697 — IC50 = 3.986 nM 8.40
CHEMBL4466125 — IC50 - — -
CHEMBL4535261 — IC50 - — -
CHEMBL4443487 — IC50 - — -
CHEMBL4475352 — IC50 - — -
CHEMBL4519563 — IC50 - — -
CHEMBL4446788 — IC50 - — -