Assay Detail
Binding
CHEMBL4422796
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Inhibition of HDAC4 (unknown origin)
8
Total Activities
8
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
HDAC as onco target: Reviewing the synthetic approaches with SAR study of their inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 7.28 | 8.70 |
| Ki | 1 | 5.85 | 5.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4438404 | — | — | 1 | 8.70 |
| CHEMBL4543038 | — | — | 1 | 8.47 |
| CHEMBL4551751 | — | — | 1 | 7.75 |
| CHEMBL4593341 | — | — | 1 | 7.75 |
| CHEMBL98 | VORINOSTAT | 4.0 | 1 | 6.47 |
| CHEMBL343448 | ROMIDEPSIN | 4.0 | 1 | 6.29 |
| CHEMBL99 | TRICHOSTATIN | 1.0 | 1 | 5.85 |
| CHEMBL4452333 | — | — | 1 | 5.52 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4438404 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL4543038 | — | IC50 | = | 3.4 | nM | 8.47 |
| CHEMBL4551751 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL4593341 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL98 | VORINOSTAT | IC50 | = | 340.0 | nM | 6.47 |
| CHEMBL343448 | ROMIDEPSIN | IC50 | = | 510.0 | nM | 6.29 |
| CHEMBL99 | TRICHOSTATIN | Ki | = | 1400.0 | nM | 5.85 |
| CHEMBL4452333 | — | IC50 | = | 3000.0 | nM | 5.52 |