Assay Detail
Functional
CHEMBL4423400
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Antiproliferative activity against human HCT116 cells after 72 hrs by MTT assay
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HCT-116 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of potent, orally bioavailable ERK1/2 inhibitors with isoindolin-1-one structure by structure-based drug design.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 6.74 | 6.83 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4476178 | — | — | 1 | 6.83 |
| CHEMBL4588783 | — | — | 1 | 6.82 |
| CHEMBL4434915 | — | — | 1 | 6.81 |
| CHEMBL4532652 | — | — | 1 | 6.70 |
| CHEMBL4571588 | — | — | 1 | 6.70 |
| CHEMBL4567212 | — | — | 1 | 6.60 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4476178 | — | IC50 | = | 148.0 | nM | 6.83 |
| CHEMBL4588783 | — | IC50 | = | 150.44 | nM | 6.82 |
| CHEMBL4434915 | — | IC50 | = | 154.97 | nM | 6.81 |
| CHEMBL4532652 | — | IC50 | = | 200.68 | nM | 6.70 |
| CHEMBL4571588 | — | IC50 | = | 201.74 | nM | 6.70 |
| CHEMBL4567212 | — | IC50 | = | 250.57 | nM | 6.60 |