Assay Detail
Binding
CHEMBL4423708
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Inhibition of VEGFR-2 (unknown origin) after 1 hrs by ADP-Glo luminescence assay
21
Total Activities
21
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Vascular endothelial growth factor receptor 2 (CHEMBL279) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Discovery of novel anti-angiogenesis agents. Part 9: Multiplex inhibitors suppressing compensatory activations of RTKs.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 21 | 7.98 | 9.28 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4472113 | — | — | 1 | 9.28 |
| CHEMBL4543212 | — | — | 1 | 9.24 |
| CHEMBL4553163 | — | — | 1 | 8.59 |
| CHEMBL4469077 | — | — | 1 | 8.50 |
| CHEMBL4539395 | — | — | 1 | 8.38 |
| CHEMBL4459732 | — | — | 1 | 8.12 |
| CHEMBL4452405 | — | — | 1 | 7.96 |
| CHEMBL4448354 | — | — | 1 | 7.25 |
| CHEMBL4476000 | — | — | 1 | 7.24 |
| CHEMBL4447942 | — | — | 1 | 6.90 |
| CHEMBL4453627 | — | — | 1 | 6.30 |
| CHEMBL1336 | SORAFENIB | 4.0 | 1 | - |
| CHEMBL4570733 | — | — | 1 | - |
| CHEMBL4516255 | — | — | 1 | - |
| CHEMBL4525897 | — | — | 1 | - |
| CHEMBL4436670 | — | — | 1 | - |
| CHEMBL4470139 | — | — | 1 | - |
| CHEMBL4575350 | — | — | 1 | - |
| CHEMBL4437530 | — | — | 1 | - |
| CHEMBL4449073 | — | — | 1 | - |
| CHEMBL4456738 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4472113 | — | IC50 | = | 0.53 | nM | 9.28 |
| CHEMBL4543212 | — | IC50 | = | 0.57 | nM | 9.24 |
| CHEMBL4553163 | — | IC50 | = | 2.57 | nM | 8.59 |
| CHEMBL4469077 | — | IC50 | = | 3.17 | nM | 8.50 |
| CHEMBL4539395 | — | IC50 | = | 4.15 | nM | 8.38 |
| CHEMBL4459732 | — | IC50 | = | 7.63 | nM | 8.12 |
| CHEMBL4452405 | — | IC50 | = | 11.06 | nM | 7.96 |
| CHEMBL4448354 | — | IC50 | = | 55.95 | nM | 7.25 |
| CHEMBL4476000 | — | IC50 | = | 58.1 | nM | 7.24 |
| CHEMBL4447942 | — | IC50 | = | 125.06 | nM | 6.90 |
| CHEMBL4453627 | — | IC50 | = | 500.28 | nM | 6.30 |
| CHEMBL1336 | SORAFENIB | IC50 | = | 0.17 | nM | - |
| CHEMBL4570733 | — | IC50 | - | — | - | |
| CHEMBL4516255 | — | IC50 | - | — | - | |
| CHEMBL4525897 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL4436670 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL4470139 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL4575350 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL4437530 | — | IC50 | - | — | - | |
| CHEMBL4449073 | — | IC50 | - | — | - | |
| CHEMBL4456738 | — | IC50 | > | 1000.0 | nM | - |