Compound Detail
CHEMBL4449073
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Basic Information
| ChEMBL ID | CHEMBL4449073 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | WMMIWDCIFRAQFR-UHFFFAOYSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
4
Publications
0
Known Names
Molecular Properties
381.4
MW (Da)
4.47
ALogP
5
HBA
0
HBD
56.5
PSA (Ų)
0.52
QED
0
Ro5 Violations
4
Rot. Bonds
Drug Information
| Molecule Type | Unknown |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 1 meas. best 4.33
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| EA.hy 926 CHEMBL4296410 | IC50 | 4.33 | 4.33 | 46840.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| EA.hy 926 | IC50 | = | 46840.0 | nM | 4.33 | Antiproliferative activity against human EAhy926 cells assessed as reduction in ... | 30616052 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 30616052 | 10.1016/j.ejmech.2018.12.067 | EA.hy 926 | 2 |
| 30616052 | 10.1016/j.ejmech.2018.12.067 | Vascular endothelial growth factor receptor 2 | 1 |
| 30616052 | 10.1016/j.ejmech.2018.12.067 | Angiopoietin-1 receptor | 1 |
| 30616052 | 10.1016/j.ejmech.2018.12.067 | Ephrin type-B receptor 4 | 1 |
Data from ChEMBL 36 via Core Engine