Assay Detail
Functional
CHEMBL4424072
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antitrypanosomal activity against Trypanosoma brucei brucei Squib 427 after 48 hrs by alamar blue assay
29
Total Activities
29
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Trypanosoma brucei brucei |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Revisiting tubercidin against kinetoplastid parasites: Aromatic substitutions at position 7 improve activity and reduce toxicity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 29 | 5.18 | 7.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL265502 | SURAMIN | 3.0 | 1 | 7.30 |
| CHEMBL4581647 | — | — | 1 | 6.51 |
| CHEMBL267099 | TUBERCIDIN | — | 1 | 6.32 |
| CHEMBL4527711 | — | — | 1 | 5.76 |
| CHEMBL4469727 | — | — | 1 | 5.71 |
| CHEMBL4580402 | — | — | 1 | 5.65 |
| CHEMBL4464277 | — | — | 1 | 5.51 |
| CHEMBL4443838 | — | — | 1 | 5.32 |
| CHEMBL4577276 | — | — | 1 | 5.32 |
| CHEMBL4451645 | — | — | 1 | 5.19 |
| CHEMBL4516812 | — | — | 1 | 5.12 |
| CHEMBL1814766 | — | — | 1 | 5.11 |
| CHEMBL4458717 | — | — | 1 | 5.09 |
| CHEMBL4462675 | — | — | 1 | 5.05 |
| CHEMBL4547306 | — | — | 1 | 5.05 |
| CHEMBL4561102 | — | — | 1 | 5.05 |
| CHEMBL4471148 | — | — | 1 | 5.00 |
| CHEMBL4518380 | — | — | 1 | 4.83 |
| CHEMBL4461564 | — | — | 1 | 4.59 |
| CHEMBL4446941 | — | — | 1 | 4.54 |
| CHEMBL1814762 | — | — | 1 | 4.49 |
| CHEMBL4448104 | — | — | 1 | 4.48 |
| CHEMBL4447530 | — | — | 1 | 4.48 |
| CHEMBL4579242 | — | — | 1 | 4.42 |
| CHEMBL1814763 | — | — | 1 | 4.38 |
| CHEMBL4458987 | — | — | 1 | 4.28 |
| CHEMBL4586792 | — | — | 1 | - |
| CHEMBL4445584 | — | — | 1 | - |
| CHEMBL4476721 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL265502 | SURAMIN | EC50 | = | 50.0 | nM | 7.30 |
| CHEMBL4581647 | — | EC50 | = | 310.0 | nM | 6.51 |
| CHEMBL267099 | TUBERCIDIN | EC50 | = | 480.0 | nM | 6.32 |
| CHEMBL4527711 | — | EC50 | = | 1750.0 | nM | 5.76 |
| CHEMBL4469727 | — | EC50 | = | 1950.0 | nM | 5.71 |
| CHEMBL4580402 | — | EC50 | = | 2260.0 | nM | 5.65 |
| CHEMBL4464277 | — | EC50 | = | 3070.0 | nM | 5.51 |
| CHEMBL4443838 | — | EC50 | = | 4770.0 | nM | 5.32 |
| CHEMBL4577276 | — | EC50 | = | 4760.0 | nM | 5.32 |
| CHEMBL4451645 | — | EC50 | = | 6450.0 | nM | 5.19 |
| CHEMBL4516812 | — | EC50 | = | 7580.0 | nM | 5.12 |
| CHEMBL1814766 | — | EC50 | = | 7830.0 | nM | 5.11 |
| CHEMBL4458717 | — | EC50 | = | 8170.0 | nM | 5.09 |
| CHEMBL4462675 | — | EC50 | = | 8920.0 | nM | 5.05 |
| CHEMBL4547306 | — | EC50 | = | 8810.0 | nM | 5.05 |
| CHEMBL4561102 | — | EC50 | = | 8970.0 | nM | 5.05 |
| CHEMBL4471148 | — | EC50 | = | 9900.0 | nM | 5.00 |
| CHEMBL4518380 | — | EC50 | = | 14700.0 | nM | 4.83 |
| CHEMBL4461564 | — | EC50 | = | 25500.0 | nM | 4.59 |
| CHEMBL4446941 | — | EC50 | = | 29100.0 | nM | 4.54 |
| CHEMBL1814762 | — | EC50 | = | 32300.0 | nM | 4.49 |
| CHEMBL4448104 | — | EC50 | = | 33300.0 | nM | 4.48 |
| CHEMBL4447530 | — | EC50 | = | 33300.0 | nM | 4.48 |
| CHEMBL4579242 | — | EC50 | = | 38200.0 | nM | 4.42 |
| CHEMBL1814763 | — | EC50 | = | 41600.0 | nM | 4.38 |
| CHEMBL4458987 | — | EC50 | = | 52400.0 | nM | 4.28 |
| CHEMBL4586792 | — | EC50 | > | 64000.0 | nM | - |
| CHEMBL4445584 | — | EC50 | > | 64000.0 | nM | - |
| CHEMBL4476721 | — | EC50 | > | 64000.0 | nM | - |