Assay Detail
Functional
CHEMBL4424073
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antitrypanosomal activity against Trypanosoma brucei rhodesiense STIB-900 after 48 hrs by alamar blue assay
29
Total Activities
29
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Trypanosoma brucei rhodesiense |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Target
Trypanosoma brucei rhodesiense (CHEMBL612348) ↗| Type | ORGANISM |
| Organism | Trypanosoma brucei rhodesiense |
Publication
Revisiting tubercidin against kinetoplastid parasites: Aromatic substitutions at position 7 improve activity and reduce toxicity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 29 | 5.50 | 7.51 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4581647 | — | — | 1 | 7.51 |
| CHEMBL265502 | SURAMIN | 3.0 | 1 | 7.40 |
| CHEMBL4464277 | — | — | 1 | 6.50 |
| CHEMBL4527711 | — | — | 1 | 6.21 |
| CHEMBL4443838 | — | — | 1 | 5.77 |
| CHEMBL4458717 | — | — | 1 | 5.44 |
| CHEMBL4451645 | — | — | 1 | 5.43 |
| CHEMBL1814762 | — | — | 1 | 5.39 |
| CHEMBL4561102 | — | — | 1 | 5.34 |
| CHEMBL4518380 | — | — | 1 | 5.21 |
| CHEMBL1814766 | — | — | 1 | 5.17 |
| CHEMBL4471148 | — | — | 1 | 5.16 |
| CHEMBL4462675 | — | — | 1 | 5.16 |
| CHEMBL4461564 | — | — | 1 | 5.09 |
| CHEMBL4547306 | — | — | 1 | 4.83 |
| CHEMBL4579242 | — | — | 1 | 4.60 |
| CHEMBL4447530 | — | — | 1 | 4.58 |
| CHEMBL4476721 | — | — | 1 | 4.25 |
| CHEMBL267099 | TUBERCIDIN | — | 1 | - |
| CHEMBL4445584 | — | — | 1 | - |
| CHEMBL4586792 | — | — | 1 | - |
| CHEMBL4469727 | — | — | 1 | - |
| CHEMBL4580402 | — | — | 1 | - |
| CHEMBL4458987 | — | — | 1 | - |
| CHEMBL4448104 | — | — | 1 | - |
| CHEMBL4577276 | — | — | 1 | - |
| CHEMBL4446941 | — | — | 1 | - |
| CHEMBL1814763 | — | — | 1 | - |
| CHEMBL4516812 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4581647 | — | EC50 | = | 31.0 | nM | 7.51 |
| CHEMBL265502 | SURAMIN | EC50 | = | 40.0 | nM | 7.40 |
| CHEMBL4464277 | — | EC50 | = | 320.0 | nM | 6.50 |
| CHEMBL4527711 | — | EC50 | = | 620.0 | nM | 6.21 |
| CHEMBL4443838 | — | EC50 | = | 1690.0 | nM | 5.77 |
| CHEMBL4458717 | — | EC50 | = | 3660.0 | nM | 5.44 |
| CHEMBL4451645 | — | EC50 | = | 3720.0 | nM | 5.43 |
| CHEMBL1814762 | — | EC50 | = | 4100.0 | nM | 5.39 |
| CHEMBL4561102 | — | EC50 | = | 4600.0 | nM | 5.34 |
| CHEMBL4518380 | — | EC50 | = | 6160.0 | nM | 5.21 |
| CHEMBL1814766 | — | EC50 | = | 6790.0 | nM | 5.17 |
| CHEMBL4471148 | — | EC50 | = | 6880.0 | nM | 5.16 |
| CHEMBL4462675 | — | EC50 | = | 6880.0 | nM | 5.16 |
| CHEMBL4461564 | — | EC50 | = | 8150.0 | nM | 5.09 |
| CHEMBL4547306 | — | EC50 | = | 14700.0 | nM | 4.83 |
| CHEMBL4579242 | — | EC50 | = | 25100.0 | nM | 4.60 |
| CHEMBL4447530 | — | EC50 | = | 26300.0 | nM | 4.58 |
| CHEMBL4476721 | — | EC50 | = | 55600.0 | nM | 4.25 |
| CHEMBL267099 | TUBERCIDIN | EC50 | - | — | - | |
| CHEMBL4445584 | — | EC50 | - | — | - | |
| CHEMBL4586792 | — | EC50 | - | — | - | |
| CHEMBL4469727 | — | EC50 | - | — | - | |
| CHEMBL4580402 | — | EC50 | - | — | - | |
| CHEMBL4458987 | — | EC50 | - | — | - | |
| CHEMBL4448104 | — | EC50 | - | — | - | |
| CHEMBL4577276 | — | EC50 | - | — | - | |
| CHEMBL4446941 | — | EC50 | - | — | - | |
| CHEMBL1814763 | — | EC50 | - | — | - | |
| CHEMBL4516812 | — | EC50 | - | — | - |