Assay Detail
Binding
CHEMBL4424210
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of recombinant human PTP1B expressed in Escherichia coli using p-nitrophenol as substrate preincubated with substrate for 5 mins followed by enzyme addition
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Tyrosine-protein phosphatase non-receptor type 1 (CHEMBL335) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Calixarene-based phosphinic acids as inhibitors of protein tyrosine phosphatases.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 6.36 | 7.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4569405 | — | — | 1 | 7.10 |
| CHEMBL4540813 | — | — | 1 | 6.42 |
| CHEMBL4530344 | — | — | 1 | 5.55 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4569405 | — | IC50 | = | 79.0 | nM | 7.10 |
| CHEMBL4540813 | — | IC50 | = | 380.0 | nM | 6.42 |
| CHEMBL4530344 | — | IC50 | = | 2800.0 | nM | 5.55 |