Assay Detail
Binding
CHEMBL4424219
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Competitive inhibition of recombinant human PTP1B expressed in Escherichia coli using varying levels of p-nitrophenol as substrate by Lineweaver-burk plot analysis
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Tyrosine-protein phosphatase non-receptor type 1 (CHEMBL335) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Calixarene-based phosphinic acids as inhibitors of protein tyrosine phosphatases.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 2 | 7.18 | 7.50 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4569405 | — | — | 1 | 7.50 |
| CHEMBL4540813 | — | — | 1 | 6.85 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4569405 | — | Ki | = | 32.0 | nM | 7.50 |
| CHEMBL4540813 | — | Ki | = | 140.0 | nM | 6.85 |