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Assay Detail

CHEMBL4424775

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Binding
Inhibition of jack bean urease assessed as reduction in ammonia production using urea as substrate after 15 mins by indophenol method
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Canavalia ensiformis
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Urease (CHEMBL4161)
Type SINGLE PROTEIN
Organism Canavalia ensiformis

Publication

Synthesis and urease inhibitory potential of benzophenone sulfonamide hybrid in vitro and in silico.
Arshia, Begum F, Almandil NB, Lodhi MA, Khan KM, Hameed A, Perveen S.
Bioorg Med Chem (2019) 27 : 1009 -1022
PubMed 30738655 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 1 8.66 8.66

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL1549559 1 8.66

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL1549559 IC50 = 2.2 nM 8.66