Assay Detail
Binding
CHEMBL4424916
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of recombinant human AChE using acetylthiocholine iodide as substrate preincubated for 5 mins followed by substrate addition and measured for 5 mins by Ellman's method
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Highly potent and selective aryl-1,2,3-triazolyl benzylpiperidine inhibitors toward butyrylcholinesterase in Alzheimer's disease.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 13 | 5.71 | 8.24 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL502 | DONEPEZIL | 4.0 | 1 | 8.24 |
| CHEMBL4534345 | — | — | 1 | 5.41 |
| CHEMBL4440392 | — | — | 1 | 5.38 |
| CHEMBL4574766 | — | — | 1 | 5.31 |
| CHEMBL4438642 | — | — | 1 | 5.31 |
| CHEMBL4557745 | — | — | 1 | 5.16 |
| CHEMBL4446441 | — | — | 1 | 5.13 |
| CHEMBL4445099 | — | — | 1 | - |
| CHEMBL4464964 | — | — | 1 | - |
| CHEMBL4467345 | — | — | 1 | - |
| CHEMBL4520568 | — | — | 1 | - |
| CHEMBL4437391 | — | — | 1 | - |
| CHEMBL4448634 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL502 | DONEPEZIL | IC50 | = | 5.7 | nM | 8.24 |
| CHEMBL4534345 | — | IC50 | = | 3940.0 | nM | 5.41 |
| CHEMBL4440392 | — | IC50 | = | 4220.0 | nM | 5.38 |
| CHEMBL4574766 | — | IC50 | = | 4900.0 | nM | 5.31 |
| CHEMBL4438642 | — | IC50 | = | 4920.0 | nM | 5.31 |
| CHEMBL4557745 | — | IC50 | = | 6900.0 | nM | 5.16 |
| CHEMBL4446441 | — | IC50 | = | 7330.0 | nM | 5.13 |
| CHEMBL4445099 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4464964 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4467345 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4520568 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4437391 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4448634 | — | IC50 | > | 10000.0 | nM | - |