Assay Detail
Binding
CHEMBL4424982
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of recombinant human NAAA expressed in HEK293 cells using [14C]-N-palmitoylethanolamine as substrate measured after 30 mins by beta-counting method
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
N-acylethanolamine-hydrolyzing acid amidase (CHEMBL4349) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Plant-Based Modulators of Endocannabinoid Signaling.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 4.39 | 4.64 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL498672 | CANNABIDIOLIC ACID | 2.0 | 1 | 4.64 |
| CHEMBL2387742 | CANNABIDIVARIN | 2.0 | 1 | 4.14 |
| CHEMBL465718 | DELTA9-TETRAHYDROCANNABINOLIC ACID A | — | 1 | - |
| CHEMBL2387541 | TETRAHYDROCANNABIVARIN | 2.0 | 1 | - |
| CHEMBL4564251 | — | — | 1 | - |
| CHEMBL190461 | CANNABIDIOL | 4.0 | 1 | - |
| CHEMBL422704 | CANNABICHROMENE | — | 1 | - |
| CHEMBL497318 | CANNABIGEROL | 2.0 | 1 | - |
| CHEMBL463843 | CANNABIGEROLIC ACID | — | 1 | - |
| CHEMBL74415 | CANNABINOL | 3.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL498672 | CANNABIDIOLIC ACID | IC50 | = | 23000.0 | nM | 4.64 |
| CHEMBL2387742 | CANNABIDIVARIN | IC50 | = | 72300.0 | nM | 4.14 |
| CHEMBL465718 | DELTA9-TETRAHYDROCANNABINOLIC ACID A | IC50 | > | 50000.0 | nM | - |
| CHEMBL2387541 | TETRAHYDROCANNABIVARIN | IC50 | > | 100000.0 | nM | - |
| CHEMBL4564251 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL190461 | CANNABIDIOL | IC50 | > | 100000.0 | nM | - |
| CHEMBL422704 | CANNABICHROMENE | IC50 | > | 100000.0 | nM | - |
| CHEMBL497318 | CANNABIGEROL | IC50 | > | 100000.0 | nM | - |
| CHEMBL463843 | CANNABIGEROLIC ACID | IC50 | > | 50000.0 | nM | - |
| CHEMBL74415 | CANNABINOL | IC50 | > | 50000.0 | nM | - |