Assay Detail
Binding
CHEMBL4425232
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Inhibition of Hsp90 in human SKBR3 cells
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Publication
Development of Heat Shock Protein (Hsp90) Inhibitors To Combat Resistance to Tyrosine Kinase Inhibitors through Hsp90-Kinase Interactions.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 7.42 | 7.62 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL383824 | ALVESPIMYCIN | 2.0 | 1 | 7.62 |
| CHEMBL109480 | TANESPIMYCIN | 3.0 | 1 | 7.48 |
| CHEMBL278315 | GELDANAMYCIN | 2.0 | 1 | 7.16 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL383824 | ALVESPIMYCIN | IC50 | = | 24.0 | nM | 7.62 |
| CHEMBL109480 | TANESPIMYCIN | IC50 | = | 33.0 | nM | 7.48 |
| CHEMBL278315 | GELDANAMYCIN | IC50 | = | 70.0 | nM | 7.16 |