Assay Detail
ADMET
CHEMBL4425261
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Binding affinity to wild type partial length human EGFR expressed in bacterial system by KINOMEscan assay
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Challenges and Perspectives on the Development of Small-Molecule EGFR Inhibitors against T790M-Mediated Resistance in Non-Small-Cell Lung Cancer.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 7 | 7.06 | 8.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1229592 | — | — | 1 | 8.92 |
| CHEMBL4454373 | — | — | 1 | 7.77 |
| CHEMBL4464614 | — | — | 1 | 6.96 |
| CHEMBL4459080 | — | — | 1 | 6.85 |
| CHEMBL4438135 | — | — | 1 | 6.51 |
| CHEMBL4446485 | — | — | 1 | 6.38 |
| CHEMBL4474541 | — | — | 1 | 6.02 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1229592 | — | Kd | = | 1.2 | nM | 8.92 |
| CHEMBL4454373 | — | Kd | = | 17.0 | nM | 7.77 |
| CHEMBL4464614 | — | Kd | = | 110.0 | nM | 6.96 |
| CHEMBL4459080 | — | Kd | = | 140.0 | nM | 6.85 |
| CHEMBL4438135 | — | Kd | = | 310.0 | nM | 6.51 |
| CHEMBL4446485 | — | Kd | = | 420.0 | nM | 6.38 |
| CHEMBL4474541 | — | Kd | = | 950.0 | nM | 6.02 |