Assay Detail
Binding
CHEMBL4425262
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity to partial length human EGFR L858R/T790M double mutant expressed in mammalian system by KINOMEscan assay
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Challenges and Perspectives on the Development of Small-Molecule EGFR Inhibitors against T790M-Mediated Resistance in Non-Small-Cell Lung Cancer.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 7 | 8.80 | 9.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1229592 | — | — | 1 | 9.52 |
| CHEMBL4454373 | — | — | 1 | 9.06 |
| CHEMBL4464614 | — | — | 1 | 8.96 |
| CHEMBL4459080 | — | — | 1 | 8.74 |
| CHEMBL4438135 | — | — | 1 | 8.59 |
| CHEMBL4446485 | — | — | 1 | 8.51 |
| CHEMBL4474541 | — | — | 1 | 8.21 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1229592 | — | Kd | = | 0.3 | nM | 9.52 |
| CHEMBL4454373 | — | Kd | = | 0.88 | nM | 9.06 |
| CHEMBL4464614 | — | Kd | = | 1.1 | nM | 8.96 |
| CHEMBL4459080 | — | Kd | = | 1.8 | nM | 8.74 |
| CHEMBL4438135 | — | Kd | = | 2.6 | nM | 8.59 |
| CHEMBL4446485 | — | Kd | = | 3.1 | nM | 8.51 |
| CHEMBL4474541 | — | Kd | = | 6.1 | nM | 8.21 |