Assay Detail
ADMET
CHEMBL4425264
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Antiproliferative activity against human A431 cells expressing wild type EGFR by MTS assay
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Homo sapiens |
| Cell Type | A-431 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Challenges and Perspectives on the Development of Small-Molecule EGFR Inhibitors against T790M-Mediated Resistance in Non-Small-Cell Lung Cancer.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 5.48 | 5.98 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1229592 | — | — | 1 | 5.98 |
| CHEMBL4454373 | — | — | 1 | 5.81 |
| CHEMBL4459080 | — | — | 1 | 5.53 |
| CHEMBL4464614 | — | — | 1 | 5.45 |
| CHEMBL4446485 | — | — | 1 | 5.28 |
| CHEMBL4438135 | — | — | 1 | 4.84 |
| CHEMBL4474541 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1229592 | — | IC50 | = | 1042.0 | nM | 5.98 |
| CHEMBL4454373 | — | IC50 | = | 1536.0 | nM | 5.81 |
| CHEMBL4459080 | — | IC50 | = | 2983.0 | nM | 5.53 |
| CHEMBL4464614 | — | IC50 | = | 3567.0 | nM | 5.45 |
| CHEMBL4446485 | — | IC50 | = | 5254.0 | nM | 5.28 |
| CHEMBL4438135 | — | IC50 | = | 14530.0 | nM | 4.84 |
| CHEMBL4474541 | — | IC50 | > | 30000.0 | nM | - |