Assay Detail
ADMET
CHEMBL4425273
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Antiproliferative activity against mouse BA/F3 cells expressing wild type EGFR after 72 hrs by MTS assay
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Mus musculus |
| Cell Type | BaF3 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Challenges and Perspectives on the Development of Small-Molecule EGFR Inhibitors against T790M-Mediated Resistance in Non-Small-Cell Lung Cancer.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 7.36 | 7.62 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1643976 | — | — | 1 | 7.62 |
| CHEMBL1643989 | — | — | 1 | 7.50 |
| CHEMBL1229592 | — | — | 1 | 6.95 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1643976 | — | IC50 | = | 24.0 | nM | 7.62 |
| CHEMBL1643989 | — | IC50 | = | 32.0 | nM | 7.50 |
| CHEMBL1229592 | — | IC50 | = | 113.0 | nM | 6.95 |