Assay Detail
Functional
CHEMBL4425397
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Cytotoxicity against human K562 cells assessed as cell growth inhibition after 24 hrs by MTT assay
107
Total Activities
107
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | K562 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Novel Benzo[a]quinolizidine Analogs Induce Cancer Cell Death through Paraptosis and Apoptosis.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 107 | 5.69 | 7.41 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL92 | DOCETAXEL ANHYDROUS | 4.0 | 1 | 7.41 |
| CHEMBL4470477 | — | — | 1 | 6.00 |
| CHEMBL4546689 | — | — | 1 | 5.97 |
| CHEMBL4559251 | — | — | 1 | 5.95 |
| CHEMBL4555926 | — | — | 1 | 5.94 |
| CHEMBL4541794 | — | — | 1 | 5.91 |
| CHEMBL4565700 | — | — | 1 | 5.87 |
| CHEMBL4556077 | — | — | 1 | 5.87 |
| CHEMBL4434945 | — | — | 1 | 5.85 |
| CHEMBL4570482 | — | — | 1 | 5.85 |
| CHEMBL4441909 | — | — | 1 | 5.84 |
| CHEMBL4541123 | — | — | 1 | 5.84 |
| CHEMBL4474556 | — | — | 1 | 5.82 |
| CHEMBL4451241 | — | — | 1 | 5.75 |
| CHEMBL4521510 | — | — | 1 | 5.74 |
| CHEMBL4545802 | — | — | 1 | 5.72 |
| CHEMBL4516304 | — | — | 1 | 5.70 |
| CHEMBL4540844 | — | — | 1 | 5.69 |
| CHEMBL4460875 | — | — | 1 | 5.64 |
| CHEMBL4456855 | — | — | 1 | 5.63 |
| CHEMBL4463467 | — | — | 1 | 5.63 |
| CHEMBL4540233 | — | — | 1 | 5.54 |
| CHEMBL4441048 | — | — | 1 | 5.50 |
| CHEMBL4471913 | — | — | 1 | 5.49 |
| CHEMBL4573743 | — | — | 1 | 5.49 |
| CHEMBL4476160 | — | — | 1 | 5.42 |
| CHEMBL4566757 | — | — | 1 | 5.41 |
| CHEMBL4470203 | — | — | 1 | 5.41 |
| CHEMBL4436250 | — | — | 1 | 5.40 |
| CHEMBL4516230 | — | — | 1 | 5.27 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL92 | DOCETAXEL ANHYDROUS | IC50 | = | 39.0 | nM | 7.41 |
| CHEMBL4470477 | — | IC50 | = | 1010.0 | nM | 6.00 |
| CHEMBL4546689 | — | IC50 | = | 1080.0 | nM | 5.97 |
| CHEMBL4559251 | — | IC50 | = | 1130.0 | nM | 5.95 |
| CHEMBL4555926 | — | IC50 | = | 1150.0 | nM | 5.94 |
| CHEMBL4541794 | — | IC50 | = | 1220.0 | nM | 5.91 |
| CHEMBL4556077 | — | IC50 | = | 1350.0 | nM | 5.87 |
| CHEMBL4565700 | — | IC50 | = | 1350.0 | nM | 5.87 |
| CHEMBL4434945 | — | IC50 | = | 1410.0 | nM | 5.85 |
| CHEMBL4570482 | — | IC50 | = | 1420.0 | nM | 5.85 |
| CHEMBL4441909 | — | IC50 | = | 1440.0 | nM | 5.84 |
| CHEMBL4541123 | — | IC50 | = | 1460.0 | nM | 5.84 |
| CHEMBL4474556 | — | IC50 | = | 1520.0 | nM | 5.82 |
| CHEMBL4451241 | — | IC50 | = | 1790.0 | nM | 5.75 |
| CHEMBL4521510 | — | IC50 | = | 1840.0 | nM | 5.74 |
| CHEMBL4545802 | — | IC50 | = | 1890.0 | nM | 5.72 |
| CHEMBL4516304 | — | IC50 | = | 1980.0 | nM | 5.70 |
| CHEMBL4540844 | — | IC50 | = | 2040.0 | nM | 5.69 |
| CHEMBL4460875 | — | IC50 | = | 2290.0 | nM | 5.64 |
| CHEMBL4456855 | — | IC50 | = | 2320.0 | nM | 5.63 |
| CHEMBL4463467 | — | IC50 | = | 2350.0 | nM | 5.63 |
| CHEMBL4540233 | — | IC50 | = | 2880.0 | nM | 5.54 |
| CHEMBL4441048 | — | IC50 | = | 3150.0 | nM | 5.50 |
| CHEMBL4471913 | — | IC50 | = | 3240.0 | nM | 5.49 |
| CHEMBL4573743 | — | IC50 | = | 3260.0 | nM | 5.49 |
| CHEMBL4476160 | — | IC50 | = | 3810.0 | nM | 5.42 |
| CHEMBL4470203 | — | IC50 | = | 3920.0 | nM | 5.41 |
| CHEMBL4566757 | — | IC50 | = | 3880.0 | nM | 5.41 |
| CHEMBL4436250 | — | IC50 | = | 3950.0 | nM | 5.40 |
| CHEMBL4516230 | — | IC50 | = | 5420.0 | nM | 5.27 |
| CHEMBL4563992 | — | IC50 | = | 5440.0 | nM | 5.26 |
| CHEMBL4552402 | — | IC50 | = | 5610.0 | nM | 5.25 |
| CHEMBL4465317 | — | IC50 | = | 6810.0 | nM | 5.17 |
| CHEMBL4470826 | — | IC50 | = | 6960.0 | nM | 5.16 |
| CHEMBL4439762 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL4558388 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL4560502 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL4459935 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL4435768 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL4467751 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL4573337 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL4473360 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL4446006 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL4453328 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL4540690 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL4436289 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL4463285 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL4440762 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL4465948 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL4455411 | — | IC50 | > | 20000.0 | nM | - |