Assay Detail
Functional
CHEMBL4425398
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Cytotoxicity against human PC3 cells assessed as cell growth inhibition after 24 hrs by MTT assay
107
Total Activities
107
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | PC-3 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Novel Benzo[a]quinolizidine Analogs Induce Cancer Cell Death through Paraptosis and Apoptosis.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 107 | 5.93 | 7.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL92 | DOCETAXEL ANHYDROUS | 4.0 | 1 | 7.89 |
| CHEMBL4470477 | — | — | 1 | 6.39 |
| CHEMBL4565700 | — | — | 1 | 6.35 |
| CHEMBL4521510 | — | — | 1 | 6.21 |
| CHEMBL4441909 | — | — | 1 | 6.18 |
| CHEMBL4555926 | — | — | 1 | 6.17 |
| CHEMBL4463467 | — | — | 1 | 6.14 |
| CHEMBL4451241 | — | — | 1 | 6.10 |
| CHEMBL4570482 | — | — | 1 | 6.09 |
| CHEMBL4541123 | — | — | 1 | 6.05 |
| CHEMBL4556077 | — | — | 1 | 5.96 |
| CHEMBL4471913 | — | — | 1 | 5.94 |
| CHEMBL4436250 | — | — | 1 | 5.94 |
| CHEMBL4541794 | — | — | 1 | 5.91 |
| CHEMBL4559251 | — | — | 1 | 5.89 |
| CHEMBL4545802 | — | — | 1 | 5.87 |
| CHEMBL4546689 | — | — | 1 | 5.87 |
| CHEMBL4516230 | — | — | 1 | 5.82 |
| CHEMBL4470203 | — | — | 1 | 5.77 |
| CHEMBL4434945 | — | — | 1 | 5.67 |
| CHEMBL4451731 | — | — | 1 | 5.64 |
| CHEMBL4465372 | — | — | 1 | 5.58 |
| CHEMBL4474556 | — | — | 1 | 5.55 |
| CHEMBL4476160 | — | — | 1 | 5.45 |
| CHEMBL4540844 | — | — | 1 | 5.42 |
| CHEMBL4573743 | — | — | 1 | 5.12 |
| CHEMBL4470826 | — | — | 1 | 5.08 |
| CHEMBL4563992 | — | — | 1 | - |
| CHEMBL4566757 | — | — | 1 | - |
| CHEMBL4456855 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL92 | DOCETAXEL ANHYDROUS | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL4470477 | — | IC50 | = | 410.0 | nM | 6.39 |
| CHEMBL4565700 | — | IC50 | = | 450.0 | nM | 6.35 |
| CHEMBL4521510 | — | IC50 | = | 610.0 | nM | 6.21 |
| CHEMBL4441909 | — | IC50 | = | 660.0 | nM | 6.18 |
| CHEMBL4555926 | — | IC50 | = | 680.0 | nM | 6.17 |
| CHEMBL4463467 | — | IC50 | = | 720.0 | nM | 6.14 |
| CHEMBL4451241 | — | IC50 | = | 790.0 | nM | 6.10 |
| CHEMBL4570482 | — | IC50 | = | 820.0 | nM | 6.09 |
| CHEMBL4541123 | — | IC50 | = | 890.0 | nM | 6.05 |
| CHEMBL4556077 | — | IC50 | = | 1110.0 | nM | 5.96 |
| CHEMBL4471913 | — | IC50 | = | 1160.0 | nM | 5.94 |
| CHEMBL4436250 | — | IC50 | = | 1150.0 | nM | 5.94 |
| CHEMBL4541794 | — | IC50 | = | 1240.0 | nM | 5.91 |
| CHEMBL4559251 | — | IC50 | = | 1290.0 | nM | 5.89 |
| CHEMBL4545802 | — | IC50 | = | 1350.0 | nM | 5.87 |
| CHEMBL4546689 | — | IC50 | = | 1360.0 | nM | 5.87 |
| CHEMBL4516230 | — | IC50 | = | 1510.0 | nM | 5.82 |
| CHEMBL4470203 | — | IC50 | = | 1710.0 | nM | 5.77 |
| CHEMBL4434945 | — | IC50 | = | 2150.0 | nM | 5.67 |
| CHEMBL4451731 | — | IC50 | = | 2270.0 | nM | 5.64 |
| CHEMBL4465372 | — | IC50 | = | 2600.0 | nM | 5.58 |
| CHEMBL4474556 | — | IC50 | = | 2810.0 | nM | 5.55 |
| CHEMBL4476160 | — | IC50 | = | 3520.0 | nM | 5.45 |
| CHEMBL4540844 | — | IC50 | = | 3790.0 | nM | 5.42 |
| CHEMBL4573743 | — | IC50 | = | 7670.0 | nM | 5.12 |
| CHEMBL4470826 | — | IC50 | = | 8370.0 | nM | 5.08 |
| CHEMBL4558388 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL4522056 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL4568298 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL4444225 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL4463285 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL4436289 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL4540690 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL4453328 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL4446006 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL4473360 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL4525583 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL4439762 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL4514850 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL4573337 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL4560502 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL4459935 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL4435768 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL4467751 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL4465948 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL4593548 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL4453564 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL4535621 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL4449944 | — | IC50 | > | 20000.0 | nM | - |