Assay Detail
Binding
CHEMBL4425528
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of ABCC1 in human H69AR cells preincubated for 30 mins before calcein AM addition by calcein AM assay
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Multidrug resistance-associated protein 1 (CHEMBL3004) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Synthesis and Biological Evaluation of 4-Anilino-quinazolines and -quinolines as Inhibitors of Breast Cancer Resistance Protein (ABCG2).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 5.30 | 5.53 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4462578 | — | — | 1 | 5.53 |
| CHEMBL4447490 | — | — | 1 | 5.43 |
| CHEMBL160 | CYCLOSPORINE | 4.0 | 1 | 5.42 |
| CHEMBL4437626 | — | — | 1 | 5.24 |
| CHEMBL120099 | — | — | 1 | 5.09 |
| CHEMBL1624741 | — | — | 1 | 5.06 |
| CHEMBL2158554 | — | — | 1 | - |
| CHEMBL1474597 | — | — | 1 | - |
| CHEMBL4455303 | — | — | 1 | - |
| CHEMBL4530796 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4462578 | — | IC50 | = | 2980.0 | nM | 5.53 |
| CHEMBL4447490 | — | IC50 | = | 3730.0 | nM | 5.43 |
| CHEMBL160 | CYCLOSPORINE | IC50 | = | 3770.0 | nM | 5.42 |
| CHEMBL4437626 | — | IC50 | = | 5800.0 | nM | 5.24 |
| CHEMBL120099 | — | IC50 | = | 8130.0 | nM | 5.09 |
| CHEMBL1624741 | — | IC50 | = | 8770.0 | nM | 5.06 |
| CHEMBL2158554 | — | IC50 | - | — | - | |
| CHEMBL1474597 | — | IC50 | - | — | - | |
| CHEMBL4455303 | — | IC50 | - | — | - | |
| CHEMBL4530796 | — | IC50 | - | — | - |