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Assay Detail

CHEMBL4425656

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Functional
Antiproliferative activity against human HCT116 cells after 24 hrs by MTT assay
ChEMBL ↗
60
Total Activities
60
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type HCT-116
Confidence 1 — Organism
Curated By Autocuration

Target

HCT-116 (CHEMBL394) ↗
Type CELL-LINE
Organism Homo sapiens

Publication

Design, Synthesis, and Evaluation of in Vitro and in Vivo Anticancer Activity of 4-Substituted Coumarins: A Novel Class of Potent Tubulin Polymerization Inhibitors.
Cao D, Liu Y, Yan W, Wang C, Bai P, Wang T, Tang M, Wang X, Yang Z, Ma B, Ma L, Lei L, Wang F, Xu B, Zhou Y, Yang T, Chen L.
J Med Chem (2016) 59 : 5721 -5739
PubMed 27213819 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 60 7.43 8.54

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL4591592 — — 1 8.54
CHEMBL4444361 — — 1 8.44
CHEMBL492399 VERUBULIN 2.0 1 8.37
CHEMBL4452015 — — 1 8.05
CHEMBL4464439 — — 1 7.91
CHEMBL4580276 — — 1 7.88
CHEMBL4454305 — — 1 7.83
CHEMBL4551726 — — 1 7.81
CHEMBL4463981 — — 1 7.76
CHEMBL4470842 — — 1 7.62
CHEMBL4440561 — — 1 7.59
CHEMBL4476029 — — 1 7.59
CHEMBL4438061 — — 1 7.57
CHEMBL107 COLCHICINE 4.0 1 7.56
CHEMBL4572582 — — 1 7.53
CHEMBL4451863 — — 1 7.53
CHEMBL4460288 — — 1 7.52
CHEMBL4538421 — — 1 7.50
CHEMBL4516562 — — 1 7.44
CHEMBL4531120 — — 1 7.35
CHEMBL4579903 — — 1 7.35
CHEMBL4517440 — — 1 7.34
CHEMBL4585086 — — 1 7.30
CHEMBL4544406 — — 1 7.19
CHEMBL4522137 — — 1 7.17
CHEMBL4448118 — — 1 7.15
CHEMBL4580532 — — 1 6.94
CHEMBL4578913 — — 1 6.83
CHEMBL4571021 — — 1 6.53
CHEMBL4451972 — — 1 6.52

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL4591592 — IC50 = 2.9 nM 8.54
CHEMBL4444361 — IC50 = 3.6 nM 8.44
CHEMBL492399 VERUBULIN IC50 = 4.3 nM 8.37
CHEMBL4452015 — IC50 = 9.0 nM 8.05
CHEMBL4464439 — IC50 = 12.3 nM 7.91
CHEMBL4580276 — IC50 = 13.3 nM 7.88
CHEMBL4454305 — IC50 = 14.8 nM 7.83
CHEMBL4551726 — IC50 = 15.4 nM 7.81
CHEMBL4463981 — IC50 = 17.5 nM 7.76
CHEMBL4470842 — IC50 = 24.1 nM 7.62
CHEMBL4440561 — IC50 = 25.6 nM 7.59
CHEMBL4476029 — IC50 = 25.4 nM 7.59
CHEMBL4438061 — IC50 = 27.2 nM 7.57
CHEMBL107 COLCHICINE IC50 = 27.8 nM 7.56
CHEMBL4451863 — IC50 = 29.5 nM 7.53
CHEMBL4572582 — IC50 = 29.7 nM 7.53
CHEMBL4460288 — IC50 = 30.1 nM 7.52
CHEMBL4538421 — IC50 = 31.9 nM 7.50
CHEMBL4516562 — IC50 = 36.4 nM 7.44
CHEMBL4531120 — IC50 = 44.4 nM 7.35
CHEMBL4579903 — IC50 = 44.4 nM 7.35
CHEMBL4517440 — IC50 = 45.6 nM 7.34
CHEMBL4585086 — IC50 = 49.6 nM 7.30
CHEMBL4544406 — IC50 = 64.1 nM 7.19
CHEMBL4522137 — IC50 = 67.2 nM 7.17
CHEMBL4448118 — IC50 = 70.9 nM 7.15
CHEMBL4580532 — IC50 = 113.9 nM 6.94
CHEMBL4578913 — IC50 = 146.7 nM 6.83
CHEMBL4571021 — IC50 = 293.3 nM 6.53
CHEMBL4451972 — IC50 = 303.5 nM 6.52
CHEMBL4471722 — IC50 = 318.9 nM 6.50
CHEMBL4534308 — IC50 = 336.6 nM 6.47
CHEMBL4570517 — IC50 = 398.2 nM 6.40
CHEMBL4441523 — IC50 > 5000.0 nM -
CHEMBL4467994 — IC50 > 5000.0 nM -
CHEMBL4578511 — IC50 > 5000.0 nM -
CHEMBL4552086 — IC50 > 5000.0 nM -
CHEMBL4548592 — IC50 > 5000.0 nM -
CHEMBL4446604 — IC50 > 5000.0 nM -
CHEMBL4462884 — IC50 > 5000.0 nM -
CHEMBL4439022 — IC50 > 5000.0 nM -
CHEMBL4457605 — IC50 > 5000.0 nM -
CHEMBL4575959 — IC50 > 5000.0 nM -
CHEMBL4437402 — IC50 > 5000.0 nM -
CHEMBL4580231 — IC50 > 5000.0 nM -
CHEMBL4545161 — IC50 > 5000.0 nM -
CHEMBL4555904 — IC50 > 5000.0 nM -
CHEMBL4473684 — IC50 > 5000.0 nM -
CHEMBL4469814 — IC50 > 5000.0 nM -
CHEMBL4451329 — IC50 > 5000.0 nM -