Assay Detail
Binding
CHEMBL4425846
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of recombinant His-tagged BRD4 bromodomain1 (unknown origin) using biotinylated ligand incubated for 10 mins by TR-FRET assay
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Diving into the Water: Inducible Binding Conformations for BRD4, TAF1(2), BRD9, and CECR2 Bromodomains.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 5.78 | 7.04 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4436408 | — | — | 1 | 7.04 |
| CHEMBL4519632 | — | — | 1 | 6.34 |
| CHEMBL4436158 | — | — | 1 | 5.60 |
| CHEMBL4460783 | — | — | 1 | 5.20 |
| CHEMBL4553271 | — | — | 1 | 4.74 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4436408 | — | IC50 | = | 92.0 | nM | 7.04 |
| CHEMBL4519632 | — | IC50 | = | 460.0 | nM | 6.34 |
| CHEMBL4436158 | — | IC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL4460783 | — | IC50 | = | 6300.0 | nM | 5.20 |
| CHEMBL4553271 | — | IC50 | = | 18400.0 | nM | 4.74 |