Assay Detail
Functional
CHEMBL4426148
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Agonist activity at human CB2 receptor expressed in HEK293 cell membranes assessed as inhibition of forskolin-stimulated cAMP accumulation after 60 mins by HTRF assay
16
Total Activities
8
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Chromenopyrazole, a Versatile Cannabinoid Scaffold with in Vivo Activity in a Model of Multiple Sclerosis.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 7.65 | 8.38 |
| Emax | 8 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4444725 | — | — | 2 | 8.38 |
| CHEMBL559612 | CP-55940 | — | 2 | 8.08 |
| CHEMBL4588694 | — | — | 2 | 7.85 |
| CHEMBL4557358 | — | — | 2 | 7.67 |
| CHEMBL4562832 | — | — | 2 | 7.59 |
| CHEMBL371214 | — | — | 2 | 7.09 |
| CHEMBL4585657 | — | — | 2 | 6.87 |
| CHEMBL497392 | — | — | 2 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4444725 | — | IC50 | = | 4.2 | nM | 8.38 |
| CHEMBL559612 | CP-55940 | IC50 | = | 8.3 | nM | 8.08 |
| CHEMBL4588694 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL4557358 | — | IC50 | = | 21.6 | nM | 7.67 |
| CHEMBL4562832 | — | IC50 | = | 25.5 | nM | 7.59 |
| CHEMBL371214 | — | IC50 | = | 81.8 | nM | 7.09 |
| CHEMBL4585657 | — | IC50 | = | 134.0 | nM | 6.87 |
| CHEMBL497392 | — | IC50 | - | — | - | |
| CHEMBL4557358 | — | Emax | = | 95.0 | % | - |
| CHEMBL4562832 | — | Emax | = | 98.0 | % | - |
| CHEMBL4585657 | — | Emax | = | 98.0 | % | - |
| CHEMBL4444725 | — | Emax | = | 101.0 | % | - |
| CHEMBL4588694 | — | Emax | = | 91.0 | % | - |
| CHEMBL559612 | CP-55940 | Emax | = | 100.0 | % | - |
| CHEMBL371214 | — | Emax | = | 98.0 | % | - |
| CHEMBL497392 | — | Emax | - | — | - |