Assay Detail
Functional
CHEMBL4426149
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Agonist activity at human CB2 receptor expressed in HEK293 cell membranes assessed as induction of [35S]-GTPgammaS binding after 60 mins by liquid scintillation spectrometric method
16
Total Activities
8
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Chromenopyrazole, a Versatile Cannabinoid Scaffold with in Vivo Activity in a Model of Multiple Sclerosis.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 8 | 7.04 | 7.41 |
| Emax | 8 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4444725 | — | — | 2 | 7.41 |
| CHEMBL4585657 | — | — | 2 | 7.30 |
| CHEMBL497392 | — | — | 2 | 7.19 |
| CHEMBL4557358 | — | — | 2 | 7.02 |
| CHEMBL4588694 | — | — | 2 | 6.27 |
| CHEMBL4562832 | — | — | 2 | - |
| CHEMBL559612 | CP-55940 | — | 2 | - |
| CHEMBL371214 | — | — | 2 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4444725 | — | EC50 | = | 38.6 | nM | 7.41 |
| CHEMBL4585657 | — | EC50 | = | 50.2 | nM | 7.30 |
| CHEMBL497392 | — | EC50 | = | 64.5 | nM | 7.19 |
| CHEMBL4557358 | — | EC50 | = | 95.1 | nM | 7.02 |
| CHEMBL4588694 | — | EC50 | = | 539.6 | nM | 6.27 |
| CHEMBL4562832 | — | EC50 | - | — | - | |
| CHEMBL559612 | CP-55940 | EC50 | - | — | - | |
| CHEMBL371214 | — | EC50 | - | — | - | |
| CHEMBL4557358 | — | Emax | = | 110.0 | % | - |
| CHEMBL4562832 | — | Emax | - | — | - | |
| CHEMBL4585657 | — | Emax | = | 114.0 | % | - |
| CHEMBL4444725 | — | Emax | = | 98.0 | % | - |
| CHEMBL4588694 | — | Emax | = | 96.0 | % | - |
| CHEMBL559612 | CP-55940 | Emax | - | — | - | |
| CHEMBL371214 | — | Emax | - | — | - | |
| CHEMBL497392 | — | Emax | = | 91.0 | % | - |